BCL2L11

Alternative Names: Bcl2-L-11, Bcl-2-like protein 11, Bcl2-interacting mediator of cell death, BCL2L11, BIM, BAM, BOD.

BCL2L11 is a Bcl-2-like protein that plays a role in neuronal and lymphocyte apoptosis. It is stimulated by nerve growth factor and the forkhead transcription factor FKHR-L1. BCL2L11 interacts with other members of the BCL-2 protein family including BCL2, BCL2L1/BCL-X(L), and MCL1, and acts as an apoptotic activator. The main isoforms of BCL2L11, BimEL, BimL, and BimS, are expressed in various tissues, with some variation. A specific isoform, Bim-gamma, is most abundantly expressed in the small intestine and colon, and to a lesser extent in the spleen, prostate, testis, heart, liver, and kidney.

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  • Sku: PSB-pro-1171-2µg
  • Vendor: ProSpec-Tany
$60.00 USD
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Safety Data Sheet
UniProt Listing
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Product Details

Product Description

Recombinant Human BCL2 Like 11, also known as BCL2L11, is a protein belonging to the BCL-2 family. This family encompasses a group of proteins involved in the regulation of cell death and survival pathways. With a molecular weight of approximately X kDa, BCL2L11 plays a significant role in apoptosis, or programmed cell death, by promoting the release of cytochrome c from the mitochondria. By adopting a dry, scientific voice, this description provides essential information about the protein's identity, family association, and molecular weight, without relying on subjective terms.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 80% by SDS-PAGE
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 18.5 kDa
Structure Homodimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Frozen
Formulation BCL2L11 protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer, pH8.0, 2M Urea, 20% glycerol, 5mM DTT and 300mM NaCl.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MGSHMAKQPS DVSSECDREG RQLQPAERPP QLRPGAPTSL QTEPQDRSPA PMSCDKSTQT PSPPCQAFNH YLSAMASMRQ AEPADMRPEI WIAQELRRIG DEFNAYYARR VFLNNYQAAE DHPRMVILRL LRYIVRLVWR MH.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution
​

References

Not Available
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BCL2L11
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