BCL2

Alternative Names: Bcl-2, BCL2, B-cell CLL/lymphoma 2, Apoptosis regulator Bcl-2

The BCL2 gene codes for a protein located on the outer membrane of mitochondria. This protein inhibits programmed cell death in certain cells, like lymphocytes. When BCL2 is constantly expressed, as seen in cases where it moves to the Ig heavy chain locus, it is believed to be responsible for follicular lymphoma. There are two different versions of the BCL2 gene, resulting from alternative splicing, which have variations in their C-terminal ends.

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  • Sku: PSB-pro-1574-5µg
  • Vendor: ProSpec-Tany
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Safety Data Sheet
UniProt Listing
NCBI Link

Product Details

Product Description

Recombinant Human B-Cell Leukemia/Lymphoma 2 (BCL-2) is a protein belonging to the BCL-2 family, which plays a significant role in regulating programmed cell death or apoptosis. With a molecular weight of approximately 26 kDa, BCL-2 is involved in the control of cell survival by inhibiting apoptosis. This protein acts as an anti-apoptotic factor, preventing the release of cytochrome c from mitochondria and thus blocking the activation of caspases. By maintaining the integrity of mitochondrial membranes, BCL-2 promotes cell survival and contributes to the regulation of various cellular processes.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 95% by SDS-PAGE
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 23.2 kDa
Structure Homodimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Frozen
Formulation BCL2 is a 0.2µm filtered concentrated solution which contains 25 mM Tris-HCl, pH 8.0, 100mM NaCl, 1 mM DTT, 30 % Glycerol, and 0.01%Tween-80.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

AHAGRTGYDN REIVMKYIHY KLSQRGYEWD AGDVGAAPPG AAPAPGIFSS QPGHTPHPAA SRDPVARTSP LQTPAAPGAA AGPALSPVPP VVHLTLRQAG DDFSRRYRRD FAEMSSQLHL TPFTARGRFA TVVEELFRDG VNWGRIVAFF EFGGVMCVES VNREMSPLVD NIALWMTEYL NRHLHTWIQD NGGWDAFVEL YGPSMRPLFD

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution
​

References

Not Available
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BCL2
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