Bcl-2 -BH4

Alternative Names: Bcl-2, BCL2, B-cell CLL/lymphoma 2, Apoptosis regulator Bcl-2

The BCL2 gene produces a protein that prevents certain cells, like lymphocytes, from undergoing apoptotic death. When the BCL2 gene is constantly expressed, as in follicular lymphoma, it is believed to be the cause of the disease. There are two versions of the BCL2 gene, each with a different C-terminal end, resulting from alternative splicing.

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  • Sku: PSB-pro-411-2µg
  • Vendor: ProSpec-Tany
$60.00 USD
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Title

Product Details

Product Description

Recombinant Human B-Cell Leukemia/Lymphoma 2 -BH4 is a protein that belongs to the Bcl-2 family, which plays a significant role in regulating cell survival and apoptosis. With a weight of approximately X kDa, this protein is involved in modulating the intrinsic apoptotic pathway by preventing the release of cytochrome c from the mitochondria. Its precise function and mechanism of action are still under investigation, making it a subject of interest in various scientific studies.

Current Lead Time

7-14 Days

Product Specifications

Species
Human
Expression System E. coli
Purity 95% by SDS-PAGE
Activity
Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
N/A
Structure Homodimer
Endotoxin Concentration
Not Available
Purification Method Not Available
Form
Lyophilized
Formulation The protein contains 10mM Tris-HCl pH-8, 1mM EDTA and 250mM NaCl.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

Check Uniprot Link

Storage Instruction

Lyophilized Bcl-2 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Bcl-2 should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.

Sample Prep Instruction

Suspend Bcl-2 in 100µl of 0.5M Acetic acid, over night at 4°C. Dilute 10 fold into selected buffer system. BCL-2 has tendency to form intramolecular disulfide bond, 5mM DTT is recommended in assay buffer. When running SDS-PAGE gel, 10mM DTT is recommended.

References

Not Available

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Bcl-2 -BH4

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