Bcl-2 (1-206 a.a.)

Alternative Names: Bcl-2, BCL2, B-cell CLL/lymphoma 2, Apoptosis regulator Bcl-2

The BCL2 gene produces a protein that prevents the death of certain cells, such as lymphocytes. When BCL2 is constantly expressed, as in the case of its relocation to the Ig heavy chain locus, it is believed to cause follicular lymphoma. Two different versions of the BCL2 gene can be produced due to alternative splicing, resulting in variations in their C-terminal ends.

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  • Sku: PSB-pro-630-2µg
  • Vendor: ProSpec-Tany
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Title

Product Details

Product Description

Recombinant Human B-Cell Leukemia/Lymphoma 2, (1-206 a.a.) is a protein derived from genetic engineering techniques that plays a significant role in various cellular processes. Belonging to the Bcl-2 family, this protein is involved in regulating apoptosis, or programmed cell death, which is crucial for maintaining tissue homeostasis. With a molecular weight of approximately 23.5 kilodaltons, this protein's structure and function have been extensively studied for its potential implications in cancer and other diseases. Understanding the intricate mechanisms of Recombinant Human B-Cell Leukemia/Lymphoma 2, (1-206 a.a.) provides valuable insights into the development of targeted therapies and interventions.

Current Lead Time

7-14 Days

Product Specifications

Species
Human
Expression System E. coli
Purity 95% by SDS-PAGE
Activity
Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
N/A
Structure Monomer
Endotoxin Concentration
Not Available
Purification Method Not Available
Form
Lyophilized
Formulation The protein contains 10mM Tris-HCl pH-8, 1mM EDTA and 250mM NaCl.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

Check Uniprot Link

Storage Instruction

Lyophilized Bcl-2 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Bcl-2 should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.

Sample Prep Instruction

Suspend Bcl-2 in 100ul of 0.5M Acetic acid, over night at 4°C.
Dilute 10 fold into selected buffer system.
BCL-2 has tendency to form intramolecular disulfide bond, 5mM DTT is recommended in assay buffer. When running SDS-PAGE gel, 10mM DTT is recommended.

References

Not Available

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Bcl-2 (1-206 a.a.)

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