BAG1

Alternative Names: BAG-1, Bcl-2-binding protein, Bcl-2-associated athanogene 1, RAP46, HAP.

BAG1 is a protein that interacts with BCL2, also known as BCL2-associated athanogene. It enhances the anti-apoptotic effects of BCL2 and acts as a connection between growth factor receptors and mechanisms that prevent cell death. BAG1 stops HSP70/HSC70 from helping other proteins fold properly by causing them to release their substrates. It also inhibits the pro-apoptotic function of PPP1R15A, further contributing to its anti-apoptotic activity. Additionally, BAG1 strengthens the ability of BCL2 to prevent cell death in response to various stimuli.

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  • Sku: PSB-pro-817-5µg
  • Vendor: ProSpec-Tany
$60.00 USD
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Safety Data Sheet
UniProt Listing
NCBI Link

Product Details

Product Description

Recombinant Human BCL2-Associated Athanogene 1 (BAG1) is a protein that belongs to the BAG family. It is involved in regulating various cellular processes, including apoptosis and stress response. With a molecular weight of approximately 50 kilodaltons, BAG1 interacts with diverse target proteins and modulates their functions. This recombinant protein is widely used in research to investigate the intricate mechanisms underlying cellular pathways and to explore potential therapeutic interventions.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 90% by SDS-PAGE
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 N/A
Structure Homodimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Frozen
Formulation BAG1 Human solution containing 20mM Tris-HCl pH-7.5, 0.1M NaCl and 10% glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MNRSQEVTRD EESTRSEEVT REEMAAAGLT VTVTHSNEKH DLHVTSQQGS SEPVVQDLAQ VVEEVIGVPQ SFQKLIFKGK SLKEMETPLS ALGIQDGCRV MLIGKKNSPQ EEVELKKLKH LEKSVEKIAD QLEELNKELT GIQQGFLPKD LQAEALCKLD RRVKATIEQF MKILEEIDTL ILPENFKDSR LKRKGLVKKV QAFLAECDTV EQNICQETER LQSTNFALAE.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution
​

References

Not Available
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BAG1
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