BAFF

Alternative Names: B-cell Activating Factor, BAFF, BLYS, CD257, TALL1, TALL-1, THANK, TNFSF13B, TNFSF20, ZTNF4

BAFF binds to receptors tnfrsf13b/taci and tnfrsf17/bcma, while Tnfsf13/april binds to the same receptors. Together, they form a pathway that stimulates b- and t-cell function and regulates humoral immunity. Additionally, a third specific baff receptor (baffr/br3) supports the survival of mature b-cells and the b-cell response. BAFF Human recombinant administration disrupts splenic B-cell and T-cell zones in mice, leading to increased levels of serum immunoglobulin.

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  • Sku: PSB-cyt-307-5µg
  • Vendor: ProSpec-Tany
$60.00 USD
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Title

Product Details

Product Description

Recombinant Human BAFF (BLyS) is a member of the tumor necrosis factor (TNF) ligand superfamily, known for its role in B cell survival and maturation. With a molecular weight of approximately 17 kDa, this protein plays a critical role in regulating the immune response by promoting B cell proliferation and differentiation. Recombinant Human BAFF is commonly used in research settings to study autoimmune diseases, lymphomas, and other immune-related disorders. Its ability to modulate B cell function makes it a valuable tool for investigating the mechanisms underlying immune system dysregulation.

Current Lead Time

7-14 Days

Product Specifications

Species
Human
Expression System E. coli
Purity 95% by SDS-PAGE
Activity
The activity is determined by a mouse splenocyte survival assay. The ED50 for this effect is 0.5-2.0µg/ml.
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
N/A
Structure Dimer
Endotoxin Concentration
Not Available
Purification Method Not Available
Form
Lyophilized
Formulation Lyophilized from a 0.2µm filtered concentrated solution in PBS, pH 7.0.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MAVQGPEETV TQDCLQLIAD SETPTIQKGS YTFVPWLLSF KRGSALEEKE NKILVKETGY FFIYGQVLYT DKTYAMGHLI QRKKVHVFGD ELSLVTLFRC IQNMPETLPN NSCYSAGIAK LEEGDELQLA IPRENAQISL DGDVTFFGAL KLL.

Storage Instruction

Lyophilized BAFF although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution BAFF should be stored at 4°C between 2-7 days and for future use below -18°C.Please prevent freeze-thaw cycles.

Sample Prep Instruction

It is recommended to reconstitute the lyophilized BAFF in sterile 18M-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

References

Not Available

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BAFF

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