AZGP1, HEK

Alternative Names: Zn-alpha-2-glycoprotein, Zn-alpha-2-GP, AZGP1, ZAG, Zinc-alpha-2-glycoprotein, ZNGP1, ZA2G. Reordered series: Zn-alpha-2-glycoprotein, Zinc-alpha-2-glycoprotein, Zn-alpha-2-GP, AZGP1, ZAG, ZNGP1, ZA2G.

Zinc-alpha-2-glycoprotein (ZAG) is a protein that is present in various body fluids. It is similar to lipid mobilizing factor (LMF), which is associated with the loss of fat in cancer cachexia. ZAG has been shown to stimulate the breakdown of fat cells. It is believed to play a role in regulating body weight and obesity, as well as controlling melanin production in melanocytes. ZAG is produced by both white and brown fat cells and may help reduce fat levels in cancer cachexia. Understanding ZAG's function could be important for managing cancer and cachexia. ZAG is structurally similar to major histocompatibility complex (MHC) proteins, but it is soluble and not attached to cell membranes. It has a groove that may bind to a specific compound, similar to how MHC proteins bind peptides or glycolipids. Despite evidence suggesting that ZAG binds to a ligand, none has been identified yet. Further research on how ZAG interacts with various compounds will help uncover the ligand(s) and understand its role in ZAG's function.

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  • Sku: PSB-pro-403-2µg
  • Vendor: ProSpec-Tany
$60.00 USD
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Safety Data Sheet
UniProt Listing
NCBI Link

Product Details

Product Description

Recombinant Human Alpha-2-Glycoprotein 1 Zinc-Binding, HEK is a protein that belongs to the alpha-2-glycoprotein family. With a weight of approximately X kDa, this protein plays a significant role in zinc binding. It is produced through recombinant DNA technology using Human Embryonic Kidney (HEK) cells. This recombinant protein offers potential applications in various research areas, including zinc metabolism, immune response modulation, and protein-protein interactions. Understanding the characteristics and functions of Recombinant Human Alpha-2-Glycoprotein 1 Zinc-Binding, HEK can provide valuable insights into its potential therapeutic and diagnostic applications.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System HEK 293
Purity 90% by SDS-PAGE
Activity
 Differentiated human SGBS adipocytes were incubated for 18 h at two dose levels of rhZA2G - 5 and 20 µg/ml. Lipolysis was quantified by measuring glycerol release into the medium using a standard protocol. Isoproterenol (10 µM) and IBMX (100 µM) were used as positive controls. "Con" stands for the negative control. There was a 3-fold increase in glycerol release with both doses. The increase was statistically significant at 5 µg/ml dose of rhZA2G (p<0.01) as well as in positive controls.
Activity Assay
Animal Component Free (ACF) No
Molecular Weight
 N/A
Structure Monomer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Lyophilized
Formulation Filtered (0.4 µm) and lyophilized in 0.5 mg/ml in 0.1M Tris-HCl pH 8.0 and 150mM NaCl.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

ASWSHPQFEK GSQENQDGRY SLTYIYTGLS KHVEDVPAFQ ALGSLNDLQF FRYNSKDRKS QPMGLWRQVEGMEDWKQDSQ LQKAREDIFM ETLKDIVEYY NDSNGSHVLQ GRFGCEIENN RSSGAFWKYY YDGKDYIEFNKEIPAWVPFD PAAQITKQKW EAEPVYVQRA KAYLEEECPA TLRKYLKYSK NILDRQDPPS VVVTSHQAPG EKKKLKCLAYDFYPGKIDVH WTRAGEVQEP ELRGDVLHNG NGTYQSWVVV AVPPQDTAPY SCHVQHSSLA QPLVVPWEAS.

Storage Instruction

Lyophilized ZA2G although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution ZA2G should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please avoid freeze-thaw cycles.

Sample Prep Instruction

Add deionized water to a working concentration approximately 0.5 mg/ml and let the lyophilized pellet dissolve completely.

References

Not Available
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AZGP1, HEK
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