AZGP1 - Human

Alternative Names: Zn-alpha-2-glycoprotein, Zn-alpha-2-GP, AZGP1, ZAG, Zinc-alpha-2-glycoprotein, ZNGP1, ZA2G. Reordered series: Zn-alpha-2-GP, Zn-alpha-2-glycoprotein, Zinc-alpha-2-glycoprotein, ZNGP1, ZA2G, ZAG, AZGP1.

Zinc-alpha-2-glycoprotein (ZAG) is present in body fluids like serum and sweat, as well as in seminal and breast cyst fluids. It shares the same amino acid sequence as lipid mobilizing factor (LMF), which is associated with the significant loss of adipose body stores in cancer cachexia. ZAG has been shown to stimulate the breakdown of fat cells both in living organisms and in laboratory settings. It has been suggested that ZAG may play a role in regulating body weight, age-related changes in obesity, and melanin production by melanocytes. ZAG is classified as a novel adipokine because it is produced by white and brown fat cells and may act on fat reduction in cachexia. Understanding ZAG's function in normal body fat regulation is important. ZAG has a similar structure to class I major histocompatibility complex (MHC) proteins but is not attached to cell membranes and does not associate with alpha-2-microglobulin in humans. Similar to MHC proteins, ZAG has a groove at the top, and x-ray crystallography has revealed a mysterious element in the same position as antigenic peptides in MHC proteins and glycolipids in CD1 isoforms. The unidentified substance is likely not a peptide and cannot be a glycolipid due to the groove's size. Like other MHC-related proteins, it is probable that ZAG's biological function depends on having a ligand occupying its

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  • Sku: PSB-pro-1605-1µg
  • Vendor: ProSpec-Tany
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Safety Data Sheet
UniProt Listing
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Product Details

Product Description

Human Alpha-2-Glycoprotein 1 Zinc-Binding, also known as AZGP1, is a zinc-binding protein that plays a role in various physiological processes. It belongs to the Alpha-2-glycoprotein family, which encompasses a group of glycoproteins involved in immune response and lipid metabolism. AZGP1 has a molecular weight of approximately X kDa and is primarily expressed in adipose tissue and certain cancer cells. This zinc-binding protein has been implicated in the regulation of lipid metabolism, tumor growth, and metastasis, making it a subject of interest in biomedical research.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System Human Serum
Purity 80% by SDS-PAGE
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) No
Molecular Weight
 32.14 kDa
Structure Homodimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Lyophilized
Formulation ZA2G protein filtered (0.4µm) and lyophilized in 0.5mg/ml in 20mM TRIS and 50mM NaCl, pH 8.0.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

QENQDGRYSL TYIYTGLSKH VEDVPAFQAL GSLNDLQFFR YNSKDRKSQP MGLWRQVEGM EDWKQDSQLQ KAREDIFMET LKDIVEYYND SNGSHVLQGR FGCEIENNRS SGAFWKYYYD GKDYIEFNKE IPAWVPFDPA AQITKQKWEA EPVYVQRAKA YLEEECPATL RKYLKYSKNI LDRQDPPSVV VTSHQAPGEK KKLKCLAYDF YPGKIDVHWT RAGEVQEPEL RGDVLHNGNG TYQSWVVVAV PPQDTAPYSC HVQHSSLAQP LVVPWEAS.

Storage Instruction

Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C. Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C.

Sample Prep Instruction

It is recommended to add deionized water to prepare a working stock solution of approximately 0.5 mg/ml and let the lyophilized pellet dissolve completely. Product is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture.

References

Not Available
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AZGP1 - Human
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