ATP6AP2

Alternative Names: Renin receptor, ATPase H(+)-transporting lysosomal accessory protein 2, ATPase H(+)-transporting lysosomal-interacting protein 2, ER-localized type I transmembrane adaptor, Embryonic liver differentiation factor 10, Renin/prorenin receptor, Vacuolar ATP synthase membrane sector-associated protein M8-9, ATP6M8-9, V-ATPase M8.9 subunit, ATP6AP2, ATP6IP2, CAPER, ELDF10, M8-9, MRXE, XMRE, XPDS, HT028, MRXSH, MSTP009, APT6M8-9.

ATPase Transporting Lysosomal Accessory Protein 2 (ATP6AP2) is a protein associated with triphosphatases (ATPases). It plays crucial roles in energy conservation, secondary active transport, acidification of intracellular compartments, and cellular pH regulation. ATP6AP2 is specifically connected to the transmembrane sector of V-type ATPases, which consist of a proton-conducting section within the membrane and a catalytic section outside of it. In addition to its role in ATPases, ATP6AP2 also functions as a receptor for the hormones renin and prorenin. This receptor activation then triggers cellular responses through the activation of ERK1 and ERK2. ATP6AP2 is found in various tissues such as the brain, heart, placenta, liver, kidney, and pancreas. However, its presence is relatively low in the lungs and skeletal muscles. Moreover, ATP6AP2 is also present in the vascular structures and syncytiotrophoblast cells within the mature fetal placenta.

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  • Sku: PSB-pro-1599-2µg
  • Vendor: ProSpec-Tany
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Safety Data Sheet
UniProt Listing
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Product Details

Product Description

Recombinant Human ATPase Transporting Lysosomal Accessory Protein 2 (ATP6AP2) is a protein that belongs to the ATPase family and plays a crucial role in lysosomal acidification and protein degradation processes. With a molecular weight of approximately 55 kDa, ATP6AP2 is involved in the assembly and activation of the vacuolar ATPase (V-ATPase) complex, which is responsible for maintaining lysosomal pH and facilitating the degradation of cellular waste. This protein's significance lies in its ability to regulate various cellular functions, making it an important target for research in the field of lysosomal disorders and related diseases.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 90% by SDS-PAGE
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 N/A
Structure Dimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Lyophilized
Formulation ATP6AP2 filtered (0.4 µm) and lyophilized from 0.5mg/ml in 20mM Tris buffer and 50mM NaCl, pH 7.5.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MKHHHHHHAS NEFSILKSPG SVVFRNGNWP IPGERIPDVA ALSMGFSVKE DLSWPGLAVG NLFHRPRATV MVMVKGVNKL ALPPGSVISY PLENAVPFSL DSVANSIHSL FSEETPVVLQ LAPSEERVYM VGKANSVFED LSVTLRQLRN RLFQENSVLS SLPLNSLSRN NEVDLLFLSE LQVLHDISSL LSRHKHLAKD HSPDLYSLEL AGLDEIGKRY GEDSEQFRDA SKILVDALQK FADDMYSLYG GNAVVELVTV KSFDTSLIRK TRTILEAKQA KNPASPYNLA YKYNFE.

Storage Instruction

Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C. Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C.

Sample Prep Instruction

It is recommended to add deionized water to prepare a working stock solution of approximately 0.5mg/ml and let the lyophilized pellet dissolve completely. ATP6AP2 is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture.

References

Not Available
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ATP6AP2
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