ATOX1

Alternative Names: Antioxidant protein 1, Copper transport protein ATOX1, Metal transport protein ATX1, ATX1, HAH1, ATOX1, MGC138453, MGC138455.

ATOX1, a member of the ATX1 family, is a metal transport protein involved in cellular antioxidant defense. It acts as a copper chaperone, binding and delivering cytosolic copper to copper ATPase proteins in the trans-Golgi network. This copper is later incorporated into ceruloplasmin. ATOX1 also functions as an antioxidant against superoxide and hydrogen peroxide, making it significant in cancer development. Due to its cytogenetic location, ATOX1 is considered a potential candidate gene for 5q-syndrome.

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  • Sku: PSB-pro-754-5µg
  • Vendor: ProSpec-Tany
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Title

Product Details

Product Description

Recombinant Human Copper Transport Protein ATOX1 is a protein involved in the transportation of copper ions within cells. Belonging to the metallochaperone family, ATOX1 plays a crucial role in delivering copper to ATP7B, a key enzyme involved in copper homeostasis. With a molecular weight of approximately 7 kDa, ATOX1 acts as an intermediary between copper import and export proteins, facilitating the proper distribution and utilization of copper ions in various cellular processes. Understanding the function and structure of ATOX1 is of great significance in elucidating copper metabolism and related disorders.

Current Lead Time

7-14 Days

Product Specifications

Species
Human
Expression System E. coli
Purity 95% by SDS-PAGE
Activity
Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
N/A
Structure Monomer
Endotoxin Concentration
Not Available
Purification Method Not Available
Form
Frozen
Formulation ATOX1 solution containing 20mM Tris pH-8, 1mM DTT and 10% glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MPKHEFSVDM TCGGCAEAVS RVLNKLGGVK YDIDLPNKKV CIESEHSMDT LLATLKKTGK TVSYLGLE.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution

References

Not Available

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ATOX1

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