ATOH1

Alternative Names: Atonal homolog 1 (Drosophila), Helix-loop-helix protein hATH-1, Class A basic helix-loop-helix protein 14, bHLHa14, HATH1, Math1.

ATOH1 collaborates with TCF3/E47 to activate E box-dependent transcription. However, this activity is solely induced by the negative regulator of neurogenesis, HES1. ATOH1 plays a role in neural cell differentiation by activating E box-dependent transcription.

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  • Sku: PSB-pro-1073-5µg
  • Vendor: ProSpec-Tany
$60.00 USD
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Title

Product Details

Product Description

Recombinant Human Atonal Homolog 1 (ATH1) is a protein that belongs to the basic helix-loop-helix (bHLH) family of transcription factors. With a molecular weight of approximately X kDa, ATH1 plays a significant role in the development and differentiation of sensory neurons in various organisms. This protein is involved in the regulation of gene expression, particularly those related to neuronal fate determination and differentiation. Understanding the functions and mechanisms of ATH1 can provide valuable insights into neurodevelopmental processes and potential therapeutic targets for neurological disorders.

Current Lead Time

7-14 Days

Product Specifications

Species
Human
Expression System E. coli
Purity 85.0% by SDS-PAGE
Activity
Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
21.3 kDa
Structure Heterodimer
Endotoxin Concentration
Not Available
Purification Method Not Available
Form
Frozen
Formulation The ATOH1 solution (1mg/1ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.4M Urea and 10% glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MKQRRLAANA RERRRMHGLN HAFDQLRNVI PSFNNDKKLS KYETLQMAQI YINALSELLQ TPSGGEQPPP PPASCKSDHH HLRTAASYEG GAGNATAAGA QQASGGSQRP TPPGSCRTRF SAPASAGGYS VQLDALHFST FEDSALTAMM AQKNLSPSLP GSILQPVQEE NSKTSPRSHR SDGEFSPHSH YSDSDEAS

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution

References

Not Available

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ATOH1

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