ATF3

Alternative Names: FLJ41705, Activating transcription factor 3, cyclic AMP-dependent transcription factor ATF-3

ATF3 is a member of the mammalian activation transcription factor/CREB protein family. It binds to the cAMP response element (CRE) found in various viral and cellular promoters. There are multiple transcript variants for ATF3, encoding two isoforms. The longer isoform inhibits transcription from promoters with ATF binding elements, while the shorter isoform, deltaZip2, promotes transcription by interacting with inhibitory co-factors. The shorter isoform does not have a leucine zipper protein-dimerization motif and does not directly bind to DNA.

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  • Sku: PSB-pka-270-5µg
  • Vendor: ProSpec-Tany
$60.00 USD
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Title

Product Details

Product Description

Recombinant Human Activating Transcription Factor-3 (ATF3) is a transcription factor belonging to the ATF/CREB family. It plays a role in cellular responses to stress and is involved in the regulation of gene expression. ATF3 has a molecular weight of approximately 21 kDa and is commonly used in research studies to investigate its functions in various biological processes.

Current Lead Time

7-14 Days

Product Specifications

Species
Human
Expression System E. coli
Purity 90% by SDS-PAGE
Activity
Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
N/A
Structure Dimer
Endotoxin Concentration
Not Available
Purification Method Not Available
Form
Frozen
Formulation ATF3 protein (1mg/ml) is supplied in 20mM Tris-HCl, pH-8, 2M Urea and 20% Glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MMLQHPGQVS ASEVSASAIV PCLSPPGSLV FEDFANLTPF VKEELRFAIQ NKHLCHRMSS ALESVTVSDR PLGVSITKAE VAPEEDERKK RRRERNKIAA AKCRNKKKEK TECLQKESEK LESVNAELKA QIEELKNEKQ HLIYMLNLHR PTCIVRAQNG RTPEDERNLF IQQIKEGTLQ S.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution

References

Not Available

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ATF3

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