ASGR2

Alternative Names: Asialoglycoprotein receptor 2, ASGPR 2, ASGP-R 2, C-type lectin domain family 4 member H2, Hepatic lectin H2, HL-2, ASGR2, CLEC4H2, HBXBP.

Asialoglycoprotein Receptor 2 (ASGR2) is a protein consisting of major and minor subunits that are encoded by distinct genes. ASGR2 is a less common subunit of the asialoglycoprotein receptor, a transmembrane protein. This receptor plays a vital role in maintaining the balance of glycoproteins in the bloodstream by facilitating their internalization and breakdown in lysosomes. Specifically, it acts on glycoproteins with exposed galactose or N-acetylgalactosamine residues.

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  • Sku: PSB-pro-1261-5µg
  • Vendor: ProSpec-Tany
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Safety Data Sheet
UniProt Listing
NCBI Link

Product Details

Product Description

Recombinant Human Asialoglycoprotein Receptor 2 is a cell surface receptor protein that plays a significant role in the clearance of desialylated glycoproteins from the circulation. Belonging to the C-type lectin family, this receptor is primarily expressed on hepatocytes, facilitating the uptake and internalization of asialoglycoproteins. With a molecular weight of approximately 43-45 kDa, this glycoprotein receptor contributes to the efficient removal of desialylated glycoproteins, thereby maintaining the homeostasis of glycoprotein metabolism.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 90% by SDS-PAGE
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 28.9 kDa
Structure Hetero-oligomer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Frozen
Formulation ASGR2 protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.2M NaCl, 30% glycerol and 1mM DTT.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MGSQSEGHRG AQLQAELRSL KEAFSNFSSS TLTEVQAIST HGGSVGDKIT SLGAKLEKQQ QDLKADHDAL LFHLKHFPVD LRFVACQMEL LHSNGSQRTC CPVNWVEHQG SCYWFSHSGK AWAEAEKYCQ LENAHLVVIN SWEEQKFIVQ HTNPFNTWIG LTDSDGSWKW VDGTDYRHNY KNWAVTQPDN WHGHELGGSE DCVEVQPDGR WNDDFCLQVY RWVCEKRRNA TGEVA.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution
​

References

Not Available
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ASGR2
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