ASCC1

Alternative Names: Activating signal cointegrator 1 complex subunit 1, ASCC1, ASC-1 complex subunit p50, ASC1p50, Trip4 complex subunit p50, CGI-18, p50.

ASCC1 is a component of the ASC-1 complex, which is involved in gene transactivation with transcription factors AP-1, NF-kB, and SRF. ASCC1 contains an N-terminal KH-type RNA-binding motif that is necessary for AP-1 transactivation by the ASC-1 complex. Mutations in ASCC1 lead to Barrett esophagus and esophageal adenocarcinoma.

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  • Sku: PSB-pro-1682-2µg
  • Vendor: ProSpec-Tany
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Title

Product Details

Product Description

Recombinant Human Activating Signal Cointegrator 1 Complex Subunit 1 (ASCC1) is a protein that plays a significant role in transcriptional regulation and chromatin remodeling. Belonging to the ASCC family, ASCC1 acts as a core component of the ASC-1 complex, which is involved in the activation of gene expression. With a molecular weight of approximately X kDa, ASCC1 interacts with various transcription factors and coactivators, facilitating the assembly of multiprotein complexes on gene promoters. This protein's functional significance and intricate involvement in gene regulation make it a subject of interest in molecular biology and biomedical research.

Current Lead Time

7-14 Days

Product Specifications

Species
Human
Expression System E. coli
Purity 90% by SDS-PAGE
Activity
Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
N/A
Structure Monomer
Endotoxin Concentration
Not Available
Purification Method Not Available
Form
Frozen
Formulation The ASCC1 solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 10% glycerol and 1mM DTT.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MGSMEVLRPQ LIRIDGRNYR KNPVQEQTYQ HEEDEEDFYQ GSMECADEPC DAYEVEQTPQ GFRSTLRAPS LLYKHIVGKR GDTRKKIEME TKTSISIPKP GQDGEIVITG QHRNGVISAR TRIDVLLDTF RRKQPFTHFL AFFLNEVEVQ EGFLRFQEEV LAKCSMDHGV DSSIFQNPKK LHLTIGMLVL LSEEEIQQTC EMLQQCKEEF INDISGGKPL EVEMAGIEYM NDDPGMVDVL YAKVHMKDGS NRLQELVDRV LERFQASGLI VKEWNSVKLH ATVMNTLFRK DPNAEGRYNL YTAEGKYIFK ERESFDGRNI LKLFENFYFG SLKLNSIHIS QRFTVDSFGN YASCGQIDFS.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution

References

Not Available

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ASCC1

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