AS3MT

Alternative Names: AS3MT, S-adenosyl-L-methionine:arsenic(III) methyltransferase, Arsenite methyltransferase, Methylarsonite methyltransferase, CYT19, RP11-753C18.6.

AS3MT is an enzyme responsible for transferring a methyl group from AdoMet to trivalent arsenic, aiding in arsenic metabolism. It methylates arsenite to create methylarsonate, which is then reduced to methylarsonite by methylarsonate reductase. Methylarsonite is further transformed into the less toxic dimethylarsinate, also known as cacodylate.

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  • Sku: PSB-enz-615-5µg
  • Vendor: ProSpec-Tany
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Title

Product Details

Product Description

Recombinant Human Arsenic Methyltransferase is an enzyme that belongs to the methyltransferase family. This enzyme plays a key role in the detoxification of arsenic by catalyzing the transfer of a methyl group from S-adenosyl-L-methionine to arsenic compounds, resulting in the formation of less toxic methylated arsenic species. Recombinant Human Arsenic Methyltransferase has a molecular weight of approximately 40 kDa and is commonly used in research studies investigating arsenic metabolism and toxicity.

Current Lead Time

7-14 Days

Product Specifications

Species
Human
Expression System E. coli
Purity 90% by SDS-PAGE
Activity
Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
44.3 kDa
Structure Dimer
Endotoxin Concentration
Not Available
Purification Method Not Available
Form
Frozen
Formulation AS3MT protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH8.0), 10% glycerol and 0.15M NaCl.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MGSHMAALRD AEIQKDVQTY YGQVLKRSAD LQTNGCVTTA RPVPKHIREA LQNVHEEVAL RYYGCGLVIP EHLENCWILD LGSGSGRDCY VLSQLVGEKG HVTGIDMTKG QVEVAEKYLD YHMEKYGFQA SNVTFIHGYI EKLGEAGIKN ESHDIVVSNCVINLVPDKQQ VLQEAYRVLK HGGELYFSDV YTSLELPEEI RTHKVLWGEC LGGALYWKEL AVLAQKIGFC PPRLVTANLI TIQNKELERV IGDCRFVSAT FRLFKHSKTG PTKRCQVIYN GGITGHEKEL MFDANFTFKE GEIVEVDEET AAILKNSRFA QDFLIRPIGE KLPTSGGCSA LELKDIITDP FKLAEESDSM KSRCVPDAAG GCCGTKKSC.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution

References

Not Available

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AS3MT

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