Artemin

Alternative Names: ART, ARTN, EVN, NBN

The protein encoded by this gene is a part of the GDNF family of ligands, which belong to the TGF-beta superfamily of signaling molecules. GDNFs have unique neurotrophic properties and are being considered for gene therapy in neurodegenerative diseases. Artemin has been shown to support the survival of various peripheral neuron populations and certain dopaminergic CNS neurons in culture. Its expression pattern near these neurons further supports its role in the PNS and CNS. This protein functions as a ligand for the RET receptor and requires GFR-alpha 3 as a coreceptor. There are four described alternatively spliced transcripts, two of which produce the same protein.

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  • Sku: PSB-cyt-306-5µg
  • Vendor: ProSpec-Tany
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Safety Data Sheet
UniProt Listing
NCBI Link

Product Details

Product Description

Recombinant Human Artemin is a protein belonging to the glial cell line-derived neurotrophic factor (GDNF) family. It plays a role in the development and maintenance of the nervous system. This protein has a molecular weight of approximately 15 kDa. Recombinant Human Artemin is commonly used in research studies to investigate its effects on neuronal growth and survival.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 98% by SDS-PAGE
Activity
 The activity is determined by the dose-dependent proliferation of the SH-SY5Y cell line and is typically 4-8 ng/mL. The activity can also be determined by its ability to promote survival and neurite outgrowth. The activity is determined by the dose-dependent proliferation of the SH-SY5Y cell line and is typically 4-8 ng/mL. The activity can also be determined by its ability to promote survival and neurite outgrowth.
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 N/A
Structure Homodimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Lyophilized
Formulation Artemin was lyophilized after extensive dialysis against 10mM sodium citrate pH-4.5 and 25mM sodium chloride.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

AGGPGSRARA AGARGCRLRS QLVPVRALGL GHRSDELVRF RFCSGSCRRA RSPHDLSLAS LLGAGALRPP PGSRPVSQPC CRPTRYEAVS FMDVNSTWRT VDRLSATACG CLG.

Storage Instruction

Lyophilized Artemin although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Artemin Human Recombinant should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.

Sample Prep Instruction

It is recommended to reconstitute the lyophilized Artemin in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

References

Not Available
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Artemin
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