ARPP19

Alternative Names: CAMP-Regulated Phosphoprotein 19kDa, CAMP-Regulated Phosphoprotein 19, Cyclic AMP Phosphoprotein 19 KD, ARPP19, ARPP-19, ARPP16, ARPP-16, Endosulfine Alpha-Like, ENSAL.

ARPP19, a protein phosphatase inhibitor, specifically inhibits protein phosphatase 2A (PP2A) during mitosis. Phosphorylation of ARPP19 at Ser-62 during mitosis allows for its interaction with PPP2R2D (PR55-delta), inhibiting its activity and leading to the inactivation of PP2A. This inactivation is essential for maintaining high cyclin-B1-CDK1 activity during M phase. Additionally, ARPP19 may indirectly enhance GAP-43 expression. With its role in obstructing protein phosphatase-2A, the 19 kDa cAMP-regulated phosphoprotein plays a critical role in regulating mitosis.

Skip to product information
  • Sku: PSB-pro-1785-5µg
  • Vendor: ProSpec-Tany
$60.00 USD
 per 
Shipping calculated at checkout.

Contact us directly for international purchases.

Title

Product Details

Product Description

Recombinant Human CAMP-Regulated Phosphoprotein, 19kDa, is a protein that plays a significant role in cellular processes. Belonging to the family of CAMP-regulated phosphoproteins, this protein is involved in signal transduction pathways and regulation of gene expression. With a molecular weight of 19 kilodaltons, it is a crucial component in various cellular functions. This recombinant protein is widely studied for its potential therapeutic applications and its importance in understanding cellular mechanisms.

Current Lead Time

7-14 Days

Product Specifications

Species
Human
Expression System E. coli
Purity 90% by SDS-PAGE
Activity
Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
14.7 kDa
Structure Homodimer
Endotoxin Concentration
Not Available
Purification Method Not Available
Form
Frozen
Formulation ARPP19 protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl and 10% glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MGSMSAEVPE AASAEEQKEM EDKVTSPEKA EEAKLKARYP HLGQKPGGSD FLRKRLQKGQ KYFDSGDYNM AKAKMKNKQL PTAAPDKTEV TGDHIPTPQD LPQRKPSLVA SKLAG.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution

References

Not Available

View full details

ARPP19

SUBHEADING

Recently viewed products