ARL14

Alternative Names: ADP-ribosylation factor-like protein 14, ADP-ribosylation factor 7, ARL14, ARF7, FLJ22595.

ARL14 is a developmentally regulated GTPase that belongs to the ARF/ARL family of Ras-related GTPases. It plays a role in recruiting MYO1E to MHC class II-containing vesicles by utilizing the effector protein C11orf46/ARF7EP. This recruitment allows ARL14 to control the movement of these vesicles along the actin cytoskeleton in dendritic cells. Additionally, the GTPase ARL14/ARF7 is responsible for controlling MHC-II transport by recruiting myosin 1E through an effector protein called ARF7EP.

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  • Sku: PSB-pro-936-5µg
  • Vendor: ProSpec-Tany
$60.00 USD
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Title

Product Details

Product Description

Recombinant Human ADP-Ribosylation Factor-Like 14 (ARL14) is a protein that belongs to the ADP-ribosylation factor (ARF) family. With a molecular weight of approximately X kDa, ARL14 plays a significant role in intracellular vesicular trafficking and membrane dynamics. It functions as a molecular switch, regulating various cellular processes such as protein sorting, membrane fusion, and cytoskeletal organization. Understanding the biochemical properties and functional mechanisms of ARL14 is crucial for unraveling its involvement in cellular processes and potential implications in disease pathways.

Current Lead Time

7-14 Days

Product Specifications

Species
Human
Expression System E. coli
Purity 90% by SDS-PAGE
Activity
Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
23.8 kDa
Structure Contact for Details
Endotoxin Concentration
Not Available
Purification Method Not Available
Form
Frozen
Formulation ARL14 protein solution (0.25mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 2mM DTT, 40% glycerol, 200mM NaCl and 1mM EDTA.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MGSLGSKNPQ TKQAQVLLLG LDSAGKSTLL YKLKLAKDIT TIPTIGFNVE MIELERNLSL TVWDVGGQEK MRTVWGCYCE NTDGLVYVVD STDKQRLEES QRQFEHILKN EHIKNVPVVL LANKQDMPGA LTAEDITRMF KVKKLCSDRN WYVQPCCALT GEGLAQGFRK LTGFVKSHMK SRGDTLAFFK QN.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution

References

Not Available

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ARL14

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