ARL1

Alternative Names: "ARFL1"

ARL1 is a member of the ARL family of proteins, which are connected to ADP-ribosylation factors (ARFs) in terms of structure. ARFs function as activators of cholera toxin (CT) ADP-ribosyltransferase activity, regulate intracellular vesicular membrane trafficking, and promote a specific variant of phospholipase D (PLD). ARL1, although weak, can stimulate PLD and CT by relying on the presence of phospholipids. As a GTP-binding protein, ARL1 is a relatively inefficient allosteric activator of the catalytic subunit of cholera toxin, an ADP-ribosyltransferase. Furthermore, ARL1 plays a role in Golgi apparatus function.

  •
  • Sku: PSB-pro-508-5µg
  • Vendor: ProSpec-Tany
$60.00 USD
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Safety Data Sheet
UniProt Listing
NCBI Link

Product Details

Product Description

Recombinant Human ADP-Ribosylation Factor-Like 1 (ARL1) is a protein belonging to the ADP-ribosylation factor (ARF) family. With a molecular weight of approximately 20 kDa, ARL1 plays a crucial role in intracellular vesicular trafficking and membrane dynamics. It functions as a molecular switch, cycling between an inactive GDP-bound state and an active GTP-bound state, thereby regulating various cellular processes such as protein trafficking, organelle biogenesis, and cytoskeletal organization. This versatile protein is involved in maintaining cellular homeostasis and is highly conserved across species, making it an important target for further research in understanding cellular mechanisms.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 95% by SDS-PAGE
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 N/A
Structure Homodimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Frozen
Formulation The ARL1 solution (0.25mg/ml) containing 20mM Tris-HCl pH-8, 2mM DTT, 100mM NaCl and 40% glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MGGFFSSIFS SLFGTREMRI LILGLDGAGK TTILYRLQVG EVVTTIPTIG FNVETVTYKN LKFQVWDLGG QTSIRPYWRC YYSNTDAVIY VVDSCDRDRI GISKSELVAM LEEEELRKAI LVVFANKQDM EQAMTSSEMA NSLGLPALKD RKWQIFKTSA TKGTGLDEAM EWLVETLKSR Q.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution
​

References

Not Available
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ARL1
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