ARHGDIB

Alternative Names: Rho GDP dissociation inhibitor (GDI) beta, Rho GDI 2, Rho-GDI beta, GDIA2, GDID4, Ly-GDI, RAP1GN1.

Members of the Rho protein family and other Ras-related small GTP-binding proteins play various roles in cellular processes, including cell cytoskeletal organization, secretion, proliferation, and signaling. These proteins are active when bound to GTP. The cycling between the GTP-bound and GDP-bound states is regulated by at least 3 types of proteins: GDP-dissociation inhibitors (GDIs), GTPase-activating proteins (GAPs), and guanine nucleotide-releasing factors (GRFs). ARHGDIB and other GDIs specifically decrease the dissociation of GDP from Ras-like GTPases.

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  • Sku: PSB-pro-1067-1µg
  • Vendor: ProSpec-Tany
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Title

Product Details

Product Description

Recombinant Human Rho GDP Dissociation Inhibitor (GDI) Beta is a protein that belongs to the Rho GDI family, which plays a crucial role in regulating the activity of Rho GTPases. With a molecular weight of approximately X kDa, this protein acts as a negative regulator by inhibiting the dissociation of GDP from Rho GTPases, thereby preventing their activation. By maintaining Rho GTPases in an inactive state, Recombinant Human Rho GDI Beta contributes to the fine-tuning of cellular processes involved in cytoskeletal organization, cell migration, and cell adhesion.

Current Lead Time

7-14 Days

Product Specifications

Species
Human
Expression System E. coli
Purity 90% by SDS-PAGE
Activity
Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
49.4 kDa
Structure Monomer
Endotoxin Concentration
Not Available
Purification Method Not Available
Form
Frozen
Formulation The ARHGDIB solution (1mg/1ml) contains phosphate-buffered Saline (pH 7.4) and 10% glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MSPILGYWKI KGLVQPTRLL LEYLEEKYEE HLYERDEGDK WRNKKFELGL EFPNLPYYID GDVKLTQSMA IIRYIADKHN MLGGCPKERA EISMLEGAVL DIRYGVSRIA YSKDFETLKV DFLSKLPEML KMFEDRLCHK TYLNGDHVTH PDFMLYDALD VVLYMDPMCL DAFPKLVCFK KRIEAIPQID KYLKSSKYIA WPLQGWQATF GGGDHPPKSD LVPRGSHMTE KAPEPHVEED DDDELDSKLN YKPPPQKSLK ELQEMDKDDE SLIKYKKTLL GDGPVVTDPK APNVVVTRLT LVCESAPGPI TMDLTGDLEA LKKETIVLKE GSEYRVKIHF KVNRDIVSGL KYVQHTYRTG VKVDKATFMV GSYGPRPEEY EFLTPVEEAP KGMLARGTYH NKSFFTDDDK QDHLSWEWNL SIKKEWTE

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution

References

Not Available

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ARHGDIB

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