ARFIP2

Alternative Names: ADP-ribosylation factor interacting protein 2, arfaptin-2, partner of RAC1 (arfaptin 2), Partner of RAC1, Protein POR1, POR1.

Arfaptin 2 (ARFIP2) is a crucial protein that binds to Rac1 and is necessary for the actin polymerization process initiated by Rac, resulting in the creation of membrane ruffles and lamellipodia. ARFIP2 is a potential target of the ADP-ribosylation factor and is also responsible for membrane ruffling. Its expression is elevated in areas of cellular degeneration. Moreover, ARFIP2 interacts with ARF6, a GTPase found in the plasma membrane and intracellular endosome vesicles, through a GTP-dependent mechanism. Additionally, Arfaptin 2 contributes to the control of mutant Huntingtin protein aggregation by impairing proteasome function.

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  • Sku: PSB-pro-1201-5µg
  • Vendor: ProSpec-Tany
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Title

Product Details

Product Description

Recombinant Human ADP-Ribosylation Factor Interacting Protein 2 (ARFIP2) is a protein that interacts with ADP-ribosylation factors (ARFs), which are key regulators of vesicular trafficking and membrane dynamics within cells. Belonging to the ARFIP family, ARFIP2 plays a role in the formation and maintenance of endosomal compartments. With a molecular weight of approximately X kilodaltons (kDa), ARFIP2 exhibits a conserved domain structure that facilitates its interaction with ARFs, enabling the regulation of intracellular transport processes. This protein's involvement in cellular membrane dynamics highlights its significance in intracellular trafficking pathways.

Current Lead Time

7-14 Days

Product Specifications

Species
Human
Expression System E. coli
Purity 90% by SDS-PAGE
Activity
Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
N/A
Structure Homodimer
Endotoxin Concentration
Not Available
Purification Method Not Available
Form
Frozen
Formulation The ARFIP2 solution (0.25mg/1ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.2M NaCl, 1mM DTT and 40% glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MGS TDGILG KAATMEIPIH GNGEARQLPE DDGLEQDLQQ VMVSGPNLNE TSIVSGGYGG SGDGLIPTGS GRHPSHSTTP SGPGDEVARG IAGEKFDIVK KWGINTYKCT KQLLSERFGR GSRTVDLELE LQIELLRETK RKYESVLQLG RALTAHLYSL LQTQHALGDA FADLSQKSPE LQEEFGYNAE TQKLLCKNGE TLLGAVNFFV SSINTLVTKT MEDTLMTVKQ YEAARLEYDA YRTDLEELSL GPRDAGTRGR LESAQATFQA HRDKYEKLRG DVAIKLKFLE ENKIKVMHKQ LLLFHNAVSA YFAGNQKQLE QTLQQFNIKL RPPGAEKPSW LEEQ

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution

References

Not Available

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ARFIP2

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