AP1S2

Alternative Names: Adaptor-related protein complex 1 sigma 2 subunit, Adaptor protein complex AP-1 sigma-1B subunit, Clathrin assembly protein complex 1 sigma-1B small chain, Golgi adaptor HA1/AP1 adaptin sigma-1B subunit, Sigma 1B subunit of AP-1 clathrin, MRX59, mental retardation X-linked 59, MGC:1902, AP-1 complex subunit sigma-2, Sigma 1B subunit of AP-1 clathrin, golgi adaptor HA1/AP1 adaptin sigma 1B subunit.

AP1S2 is a member of the adaptin protein family and acts as the small subunit of AP-1 complex 1, located on the cytoplasmic side of coated vesicles at the Golgi complex. This complex plays a crucial role in two main processes: ensuring the presence of clathrin on the membrane and recognizing specific signals within the cytosolic tails of transmembrane receptors.

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  • Sku: PSB-pro-234-2µg
  • Vendor: ProSpec-Tany
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Safety Data Sheet
UniProt Listing
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Product Details

Product Description

Recombinant Human Adaptor-Related Protein Complex 1, Sigma 2 (AP1S2) is a protein that belongs to the adaptor protein complex family. With a molecular weight of approximately X kDa, AP1S2 plays a role in intracellular protein trafficking and vesicular transport. This protein is involved in the formation of clathrin-coated vesicles at the trans-Golgi network and endosomes, facilitating the sorting and delivery of cargo molecules. Understanding the functions and mechanisms of AP1S2 can provide insights into various cellular processes and potentially contribute to the development of therapeutic interventions.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 85.0% by SDS-PAGE
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 20.7 kDa
Structure Homodimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Frozen
Formulation AP1S2 protein solution (0.5mg/1ml) containing 20mM Tris-HCl buffer (pH8.0), 40% glycerol, 0.1M NaCl and 2mM DTT.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MQFMLLFSRQ GKLRLQKWYV PLSDKEKKKI TRELVQTVLA RKPKMCSFLE WRDLKIVYKR YASLYFCCAI EDQDNELITL EIIHRYVELL DKYFGSVCEL DIIFNFEKAY FILDEFLLGG EVQETSKKNV LKAIEQADLL QEEAETPRSV LEEIGLT

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution
​

References

Not Available
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AP1S2
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