AP1AR

Alternative Names: AP-1 complex-associated regulatory protein, Adapter-related protein complex 1-associated regulatory protein, Gamma-1-adaptin brefeldin A resistance protein, Gamma-BAR, Gamma-A1-adaptin and kinesin interactor, Gadkin, AP1AR, C4orf16, PRO0971, 2c18.

AP1AR is a crucial protein for AP-1 dependent transport between the trans-Golgi network and endosomes. It regulates the membrane association of AP1G1/Gamma1-adaptin, a subunit of the AP-1 adapter complex. AP1AR acts as an effector of AP-1 in calcium-induced endo-lysosome secretion. Its interaction with AP1G1/Gamma1-adaptin reduces the release of the AP-1 complex from membranes.

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  • Sku: PSB-pro-1696-2µg
  • Vendor: ProSpec-Tany
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Safety Data Sheet
UniProt Listing
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Product Details

Product Description

Recombinant Human Adaptor-Related Protein Complex 1 Associated Regulatory Protein (AP1AR) is a member of the adaptor-related protein complex family, which plays a crucial role in intracellular vesicle trafficking. With a molecular weight of approximately X kDa, AP1AR acts as a regulatory protein involved in the formation and sorting of clathrin-coated vesicles at the trans-Golgi network. This protein contributes to the maintenance of cellular homeostasis by facilitating the transport of cargo proteins between various cellular compartments. Its intricate involvement in vesicular transport processes makes AP1AR an intriguing target for further investigation in understanding cellular dynamics and related pathologies.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 90% by SDS-PAGE
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 N/A
Structure Dimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Frozen
Formulation The AP1AR solution (0.25mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 10% glycerol and 1mM DTT.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MGNCCWTQCF GLLRKEAGRL QRVGGGGGSK YFRTCSRGEH LTIEFENLVE SDEGESPGSS HRPLTEEEIV DLRERHYDSI AEKQKDLDKK IQKELALQEE KLRLEEEALY AAQREAARAA KQRKLLEQER QRIVQQYHPS NNGEYQSSGP EDDFESCLRN MKSQYEVFRS SRLSSDATVL TPNTESSCDL MTKTKSTSGN DDSTSLDLEW EDEEGMNRML PMRERSKTEE DILRAALKYS NKKTGSNPTS ASDDSNGLEW ENDFVSAEMD DNGNSEYSGF VNPVLELSDS GIRHSDTDQQ TR.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution
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References

Not Available
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AP1AR
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