ANXA8

Alternative Names: ANX8, Annexin-8, Annexin VII, Vascular anticoagulant-beta, VAC-beta

ANXA8 is a member of the annexin protein family, which is known for its ability to bind calcium ions and phospholipids. It serves as an anticoagulant by indirectly inhibiting the thromboplastin-specific complex, a key component of the blood coagulation process. Unlike Annexin A5, ANXA8 is expressed at a much lower level in tissues where both proteins are present. However, it is highly expressed in acute promyelocytic leukemia (APL) cells, indicating its potential role in the differentiation of hematopoietic cells.

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  • Sku: PSB-pro-548-5µg
  • Vendor: ProSpec-Tany
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Title

Product Details

Product Description

Recombinant Human Annexin A8 is a protein that belongs to the annexin family, which consists of calcium-dependent phospholipid-binding proteins. With a molecular weight of approximately X kDa, this protein plays a role in various cellular processes such as membrane organization, signal transduction, and vesicle trafficking. Recombinant Human Annexin A8 is widely studied due to its involvement in cell membrane dynamics and its potential implications in diseases related to membrane dysfunction.

Current Lead Time

7-14 Days

Product Specifications

Species
Human
Expression System E. coli
Purity 90% by SDS-PAGE
Activity
Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
N/A
Structure Homodimer
Endotoxin Concentration
Not Available
Purification Method Not Available
Form
Frozen
Formulation The ANXA8 1mg/ml protein solution contains 20mM Tris-HCL pH-8, 1mM DTT,1mM EDTA, 0.1M NaCl and 10% Glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MAWWKSWIEQ EGVTVKSSSH FNPDPDAETL YKAMKGIGTN EQAIIDVLTK RSNTQRQQIA KSFKAQFGKD LTETLKSELS GKFERLIVAL MYPPYRYEAK ELHDAMKGLG TKEGVIIEIL ASRTKNQLRE IMKAYEEDYG SSLEEDIQAD TSGYLERILV CLLQGSRDDV SSFVDPGLAL QDAQDLYAAG EKIRGTDEMK FITILCTRSA THLLRVFEEY EKIANKSIED SIKSETHGSL EEAMLTVVKC TQNLHSYFAE RLYYAMKGAG TRDGTLIRNI VSRSEIDLNL IKCHFKKMYG KTLSSMIMED TSGDYKNALL SLVGSDP.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution

References

Not Available

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ANXA8

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