ANGPTL3, HEK

Alternative Names: Angiopoietin 5, ANGPT5, Angiopoietin Like Protein 3, ANGPTL3

ANGPTL3 and ANGPTL4, secreted mostly by the liver, regulate triglyceride metabolism by inhibiting lipolysis of triglyceride-rich lipoproteins. These proteins play a role in adjusting circulating triglyceride levels during feeding and fasting by affecting Lipoprotein lipase (LPL) activity. Experimental data demonstrates that ANGPTL3 shares similarities with angiopoietins. Deletion mutants of human Angiopoietin 5 indicate that the N-terminal domain (fragment 17-207) rather than the C-terminal fibrinogen-like domain (fragment 207-460) raises plasma triglyceride levels in mice.

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  • Sku: PSB-cyt-766-2µg
  • Vendor: ProSpec-Tany
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Safety Data Sheet
UniProt Listing
NCBI Link

Product Details

Product Description

Recombinant Human Angiopoietin-like Protein 3, HEK is a member of the angiopoietin-like protein family, which plays a key role in regulating lipid metabolism and energy homeostasis. This protein is produced in Human Embryonic Kidney cells (HEK) using recombinant DNA technology. With a molecular weight of approximately 60 kDa, Recombinant Human Angiopoietin-like Protein 3, HEK is involved in modulating triglyceride levels and has potential implications for metabolic disorders.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System HEK 293
Purity 95% by SDS-PAGE
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) No
Molecular Weight
 52.6 kDa
Structure Homodimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Lyophilized
Formulation Filtered (0.4µm) and lyophilized from 0.5mg/ml in 0.05M phosphate buffer and 0.075M NaCl, pH 7.4.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

SRIDQDNSSF DSLSPEPKSR FAMLDDVKIL ANGLLQLGHG LKDFVHKTKG QINDIFQKLN IFDQSFYDLS LQTSEIKEEE KELRRTTYKL QVKNEEVKNM SLELNSKLES LLEEKILLQQ KVKYLEEQLT NLIQNQPETP EHPEVTSLKT FVEKQDNSIK DLLQTVEDQY KQLNQQHSQI KEIENQLRRT SIQEPTEISL SSKPRAPRTT PFLQLNEIRN VKHDGIPAEC TTIYNRGEHT SGMYAIRPSN SQVFHVYCDV ISGSPWTLIQ HRIDGSQNFN ETWENYKYGF GRLDGEFWLG LEKIYSIVKQ SNYVLRIELE DWKDNKHYIE YSFYLGNHET NYTLHLVAIT GNVPNAIPEN KDLVFSTWDH KAKGHFNCPE GYSGGWWWHD ECGENNLNGK YNKPRAKSKP ERRRGLSWKS QNGRLYSIKS TKMLIHPTDS ESFEHHHHHH.

Storage Instruction

Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time. Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time.

Sample Prep Instruction

It is recommended to add deionized water to a working concentration of 0.5mg/ml and let the lyophilized pellet dissolve completely. Product is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture.

References

Not Available
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ANGPTL3, HEK
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