ANGPTL3 (17-460)

Alternative Names: Not Available

ANGPTL3 and ANGPTL4, primarily produced by the liver, regulate triglyceride metabolism by inhibiting lipolysis of triglyceride-rich lipoproteins. Their levels fluctuate during feeding and fasting states, affecting circulating triglyceride levels by selectively inhibiting Lipoprotein Lipase (LPL). Experimental evidence demonstrates the similarity of ANGPTL3's structure to vascular endothelial growth factors. Deletion mutants of human Angiopoietin 5 showed that the N-terminal domain fragment (17-207) increased plasma triglyceride levels in mice, while the C-terminal fibrinogen-like domain (207-460) did not.

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  • Sku: PSB-cyt-986-2µg
  • Vendor: ProSpec-Tany
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Title

Product Details

Product Description

Recombinant Human Angiopoietin-like Protein 3, (17-460 a.a.) is a member of the angiopoietin-like protein family. This protein plays a role in lipid metabolism and is involved in regulating triglyceride levels in the blood. With a molecular weight of approximately 55 kDa, Recombinant Human Angiopoietin-like Protein 3 is a promising target for research in the field of cardiovascular disease and metabolic disorders.

Current Lead Time

7-14 Days

Product Specifications

Species
Human
Expression System Sf9 - Baculovirus cells
Purity 90% by SDS-PAGE
Activity
Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
52.9 kDa
Structure Homodimer
Endotoxin Concentration
Not Available
Purification Method Not Available
Form
Frozen
Formulation ANGPTL3 protein solution (0.25mg/ml) contains Buffered Saline (pH 7.4),30% glycerol And 1mM DTT.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

ADPSRIDQDN SSFDSLSPEP KSRFAMLDDV KILANGLLQL GHGLKDFVHK TKGQINDIFQ KLNIFDQSFY DLSLQTSEIK EEEKELRRTT YKLQVKNEEV KNMSLELNSK LESLLEEKIL LQQKVKYLEE QLTNLIQNQP ETPEHPEVTS LKTFVEKQDN SIKDLLQTVE DQYKQLNQQH SQIKEIENQL RRTSIQEPTE ISLSSKPRAP RTTPFLQLNE IRNVKHDGIP AECTTIYNRG EHTSGMYAIR PSNSQVFHVY CDVISGSPWT LIQHRIDGSQ NFNETWENYK YGFGRLDGEF WLGLEKIYSI VKQSNYVLRI ELEDWKDNKH YIEYSFYLGN HETNYTLHLV AITGNVPNAI PENKDLVFST WDHKAKGHFN CPEGYSGGWW WHDECGENNL NGKYNKPRAK SKPERRRGLS WKSQNGRLYS IKSTKMLIHP TDSESFEHHH HHH.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution

References

Not Available

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ANGPTL3 (17-460)

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