ANGPTL3

Alternative Names: ANGPT5, Angiopoietin 5, ANGPTL3, Angiopoietin Like Protein 3

ANGPTL3 and ANGPTL4 are liver-secreted proteins that regulate triglyceride metabolism by inhibiting lipolysis of triglyceride-rich lipoproteins. Experimental data shows that these proteins play a role in modulating circulating triglyceride levels during feeding and fasting states by inhibiting Lipoprotein lipase. The structure of ANGPTL3 is similar to angiopoietins, and deletion mutants of human Angiopoietin 5 indicate that the N-terminal domain, rather than the C-terminal fibrinogen-like domain, increases plasma triglyceride levels in mice.

  •
  • Sku: PSB-cyt-248-2µg
  • Vendor: ProSpec-Tany
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Safety Data Sheet
UniProt Listing
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Product Details

Product Description

Recombinant Human Angiopoietin-like Protein 3 is a member of the angiopoietin-like protein family, known for its role in regulating lipid metabolism and glucose homeostasis. This protein has a molecular weight of approximately 50 kDa and is involved in the regulation of triglyceride levels in the blood. Recombinant Human Angiopoietin-like Protein 3 is commonly used in research studies to investigate its potential therapeutic applications in metabolic disorders.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 95% by SDS-PAGE
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 N/A
Structure Homodimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Lyophilized
Formulation ANGPTL3 Human filtered and lyophilized from 0.5 mg/ml in 0.05M Acetate buffer pH-4.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MRGSHHHHHH GMASHMSRID QDNSSFDSLS PEPKSRFAML DDVKILANGL LQLGHGLKDF VHKTKGQIND IFQKLNIFDQ SFYDLSLQTS EIKEEEKELR RTTYKLQVKN EEVKNMSLEL NSKLESLLEE KILLQQKVKY LEEQLTNLIQ NQPETPEHPE VTSLKTFVEK QDNSIKDLLQ TVEDQYKQLN QQHSQIKEIE NQLRRTSIQE PTEISLSSKP RAP.

Storage Instruction

Store lyophilized ANGPTL3 Human at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted Angiopoietin 5 can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C. Store lyophilized ANGPTL3 Human at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted Angiopoietin 5 can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C.

Sample Prep Instruction

Add 0.1M Acetate buffer pH-4 and let the lyophilized pellet of ANGPTL3 Human dissolve completely. For conversion into higher pH value, we recommend intensive dilution by relevant buffer to a concentration of 10μg/ml. In higher concentrations the solubility of Angiopoietin 5 is limited.

References

Not Available
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ANGPTL3
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