Angiostatin K1-4

Alternative Names: Not Available

There are various protein fragments or specific domains that inhibit angiogenesis. These include fragments of plasminogen such as Angiostatin kringles 1-4 and 1-5, Endostatin, Restin, PEX, the N-terminal fragment of prolactin, and the N-terminally truncated platelet factor. Angiostatin is a proteolytic protein fragment of plasminogen consisting of the first 4 kringle regions. Angiostatin k1-4 inhibits the growth of endothelial cells and primary carcinomas in mice when administered systemically. Angiostatin kringles 1-3 has a higher inhibitory activity than the kringles 1-4 fragment. Angiostatin kringles 1-5, which is protease-activated, has over 50 times greater inhibitory activity against endothelial cells. Systemic administration of Angiostatin kringles 1-5 inhibits fibrosarcoma growth and significantly reduces neovascularization. Angiostatin is a 38 kDa protein fragment of plasminogen found in mouse serum and urine. It is composed of the first 4 kringle domains of plasminogen and is also referred to as plasminogen kringles 1-4 and PK1-4. Angiostatin is produced by the proteolytic cleavage of plasminogen by a serine prote

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  • Sku: PSB-pro-604-2µg
  • Vendor: ProSpec-Tany
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Title

Product Details

Product Description

Human Angiostatin Kringles 1-4 is a naturally occurring protein fragment that plays a significant role in inhibiting angiogenesis, the formation of new blood vessels. Belonging to the Kringle domain family, it is a crucial component in regulating blood vessel growth and development. With a molecular weight of approximately X kilodaltons, this protein fragment exhibits potent anti-angiogenic properties, making it a promising candidate for therapeutic interventions targeting tumor growth and metastasis. Its precise mechanism of action involves binding to specific receptors on endothelial cells, thereby preventing the formation of new blood vessels necessary for tumor nourishment.

Current Lead Time

7-14 Days

Product Specifications

Species
Human
Expression System Human Fluid
Purity 98% by SDS-PAGE
Activity
Human Angiostatin Kringles 1-4 significantly inhibits basic-FGF induced endothelial cell proliferation and migration at concentration ranging from 300nM-1.0 uM. Human Angiostatin Kringles 1-4 significantly inhibits basic-FGF induced endothelial cell proliferation and migration at concentration ranging from 300nM-1.0 uM.
Activity Assay
Animal Component Free (ACF) No
Molecular Weight
N/A
Structure Monomer
Endotoxin Concentration
Not Available
Purification Method Not Available
Form
Lyophilized
Formulation Lyophilized from a (1mg/ml) solution in containing 20mM Hepes buffer pH-8.2 & 20mM NaCl.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Storage Instruction

Lyophilized Angiostatin Kringles 1-4 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Angiostatin Kringles1-4 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.

Sample Prep Instruction

It is recommended to reconstitute the lyophilized Angiostatin K1-4 in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

References

Not Available

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Angiostatin K1-4

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