AKR1C1

Alternative Names: 20-alpha-HSD, 2-ALPHA-HSD, AKR1C1, Aldo-keto reductase family 1 member C1, C9, Chlordecone reductase homolog HAKRC, DD1, DD1/DD2, DDH, DDH1, Dihydrodiol dehydrogenase 1/2, H-37, HBAB, HAKRC, High-affinity hepatic bile acid-binding protein, Indanol dehydrogenase, MGC8954, MBAB, Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase, 20-alpha-hydroxysteroid dehydrogenase

AKR1C1 is an enzyme in the aldo/keto reductase family that converts ketones and aldehydes to alcohols using cofactors like NADH and NADPH. It specifically reduces progesterone to 20-alpha-hydroxy-progesterone.

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  • Sku: PSB-enz-1130-2µg
  • Vendor: ProSpec-Tany
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Safety Data Sheet
UniProt Listing
NCBI Link

Product Details

Product Description

Recombinant Human Aldo-Keto Reductase Family 1 Member C1, also known as AKR1C1, is a member of the aldo-keto reductase family. This enzyme plays a role in the metabolism of steroid hormones and prostaglandins. AKR1C1 has a molecular weight of approximately 37 kDa. Its function in the reduction of aldehydes and ketones makes it a crucial player in various cellular processes.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 95.0 by SDS-PAGE
Activity
 Specific activity is > 500pmol/min/ug. It is defined by the amount of enzyme that catalyzes oxidation of 1.0pmole 1-Acenaphthenol in the presence of NADP per minute at pH 8.8 at 25˚C.
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 N/A
Structure Dimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Frozen
Formulation The AKR1C1 solution (1mg/ml) contains 20% Glycerol, 0.1M NaCl and 20mM Tris-HCl buffer (pH 8.5).

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MDSKYQCVKL NDGHFMPVLG FGTYAPAEVP KSKALEATKL AIEAGFRHID SAHLYNNEEQ VGLAIRSKIA DGSVKREDIF YTSKLWCNSH RPELVRPALE RSLKNLQLDY VDLYLIHFPV SVKPGEEVIP KDENGKILFD TVDLCATWEA VEKCKDAGLA KSIGVSNFNR RQLEMILNKP GLKYKPVCNQ VECHPYFNQR KLLDFCKSKD IVLVAYSALG SHREEPWVDP NSPVLLEDPVLCALAKKHKR TPALIALRYQ LQRGVVVLAK SYNEQRIRQN VQVFEFQLTS EEMKAIDGLN RNVRYLTLDI FAGPPNYPFS DEY

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution
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References

Not Available
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AKR1C1
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