AKR1A1

Alternative Names: Alcohol dehydrogenase, Alcohol dehydrogenase [NADP+], ALR, ARM, Aldehyde reductase, Aldo-keto reductase family 1 member A1, ALDR1, AKR1A1, DD3, MGC1380, MGC12529.

AKR1A1, a member of the aldo/keto reductase superfamily, catalyzes the reduction of aromatic and aliphatic aldehydes to their corresponding alcohols in an NADPH-dependent manner. This enzyme shares 65% identity with aldose reductase, which plays a role in the development of diabetic and galactosemic complications. Additionally, AKR1A1 is involved in activating procarcinogens like polycyclic aromatic hydrocarbon trans-dihydrodiols, as well as in metabolizing xenobiotics and drugs.

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  • Sku: PSB-enz-464-5µg
  • Vendor: ProSpec-Tany
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Title

Product Details

Product Description

Recombinant Human Aldo-Keto Reductase Family 1 Member A1 (AKR1A1) is a member of the aldo-keto reductase family, which plays a role in the metabolism of endogenous and exogenous aldehydes and ketones. AKR1A1 has a molecular weight of approximately 36 kDa and is involved in the reduction of a wide range of substrates, including sugars, steroids, and lipid peroxidation products. This enzyme is essential for maintaining cellular redox balance and detoxifying reactive carbonyl compounds.

Current Lead Time

7-14 Days

Product Specifications

Species
Human
Expression System E. coli
Purity 90% by SDS-PAGE
Activity
Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
N/A
Structure Dimer
Endotoxin Concentration
Not Available
Purification Method Not Available
Form
Frozen
Formulation AKR1A1 solution containing 20mM Tris pH-8, 50mM NaCl and 10% glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MAASCVLLHT GQKMPLIGLG TWKSEPGQVK AAVKYALSVG YRHIDCAAIY GNEPEIGEAL KEDVGPGKAV PREELFVTSK LWNTKHHPED VEPALRKTLA DLQLEYLDLY LMHWPYAFER GDNPFPKNAD GTICYDSTHY KETWKALEAL VAKGLVQALG LSNFNSRQID DILSVASVRP AVLQVECHPY LAQNELIAHC QARGLEVTAY SPLGSSDRAW RDPDEPVLLE EPVVLALAEKYGRSPAQILL RWQVQRKVIC IPKSITPSRI LQNIKVFDFT FSPEEMKQLN ALNKNWRYIV PMLTVDGKRV PRDAGHPLYP FNDPY

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution

References

Not Available

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AKR1A1

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