AK4

Alternative Names: Adenylate Kinase 4, Adenylate Kinase 3, Adenylate Kinase 3-like 1, ATP-AMP transphosphorylase, GTP:AMP phosphotransferase, mitochondrial adenylate kinase-3, AK3, AK3L1, AK3L2, MGC166959, EC 2.7.4.3.

AK4 is an enzyme belonging to the adenylate kinase family. It is found exclusively in the mitochondrial matrix. Adenylate kinases play a crucial role in regulating the structures of adenine and guanine nucleotides within cells by facilitating the transfer of phosphate groups between these nucleotides. Mutations in AK4 that lead to deficiencies in erythrocytes have been linked to the development of hemolytic anemia.

  •
  • Sku: PSB-pka-267-5µg
  • Vendor: ProSpec-Tany
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Safety Data Sheet
UniProt Listing
NCBI Link

Product Details

Product Description

Recombinant Human Adenylate Kinase 4 is a protein belonging to the adenylate kinase family. With a molecular weight of approximately 22 kDa, this enzyme plays a significant role in cellular energy metabolism by catalyzing the reversible transfer of phosphate groups between adenine nucleotides. Adenylate Kinase 4 is involved in maintaining the cellular energy homeostasis and regulating the levels of ATP and AMP. Its precise functions and interactions within the cell make it a subject of interest in various research fields, including biochemistry and molecular biology.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 90% by SDS-PAGE
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 27.4 kDa
Structure Homodimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Frozen
Formulation AK4 Human solution (1mg/1ml) containing 20mM Tris-HCl pH-8, 2mM DTT, 0.1M NaCl, and 10% glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MASKLLRAVI LGPPGSGKGT VCQRIAQNFG LQHLSSGHFL RENIKASTEV GEMAKQYIEK SLLVPDHVIT RLMMSELENR RGQHWLLDGF PRTLGQAEAL DKICEVDLVI SLNIPFETLK DRLSRRWIHP PSGRVYNLDF NPPHVHGIDD VTGEPLVQQE DDKPEAVAAR LRQYKDVAKP VIELYKSRGV LHQFSGTETN KIWPYVYTLF SNKITPIQSK EAY

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution
​

References

Not Available
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AK4
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