AK1

Alternative Names: Adenylate kinase isoenzyme 1, AK 1, ATP-AMP transphosphorylase 1, AK1, Myokinase.

AK1 is a vital enzyme that is responsible for cell growth and maintenance. It plays a crucial role in regulating the composition of adenine nucleotides within cells. By facilitating the transfer of the terminal phosphate group between ATP and AMP, AK1 controls this process. The protein is primarily located in the cytosol of skeletal muscle, brain, and erythrocytes. Mutations in the AK1 gene have been linked to a specific type of hemolytic anemia.

  •
  • Sku: PSB-pka-316-5µg
  • Vendor: ProSpec-Tany
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Safety Data Sheet
UniProt Listing
NCBI Link

Product Details

Product Description

Recombinant Human Adenylate Kinase 1 is a protein that belongs to the adenylate kinase family. With a weight of approximately 22.5 kDa, this enzyme plays a significant role in cellular energy metabolism by catalyzing the reversible transfer of phosphate groups between adenine nucleotides. Its precise function involves the conversion of ATP to ADP, facilitating the efficient utilization of energy within cells. Recombinant Human Adenylate Kinase 1 is widely studied due to its relevance in various biological processes, making it a valuable tool for research and pharmaceutical applications.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 95% by SDS-PAGE
Activity
 Specific activity: > 600 units/mg. One unit will convert 2.0 umoles of ADP to ATP + AMP per minute at pH 7.5 at 25°C.
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 23.7 kDa
Structure Homodimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Frozen
Formulation The AK1 protein solution (1mg/ml) contains 20mM Tris-HCl pH-7.5 and 10% glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MEEKLKKTKI IFVVGGPGSG KGTQCEKIVQ KYGYTHLSTG DLLRSEVSSG SARGKKLSEI MEKGQLVPLE TVLDMLRDAM VAKVNTSKGF LIDGYPREVQ QGEEFERRIG QPTLLLYVDA GPETMTQRLL KRGETSGRVD DNEETIKKRL ETYYKATEPV IAFYEKRGIV RKVNAEGSVD SVFSQVCTHL DALK.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution
​

References

Not Available
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AK1
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