AITRL, T7

Alternative Names: Tumor necrosis factor ligand superfamily member 18, TNFSF18, Activation-induced TNFR member Ligand, AITRL, Glucocorticoid-induced TNF-related ligand, Osteostat, GITRL, hGITRL, TL6, MGC138237.

Osteostat is a cytokine that binds to TNFRSF18/AITR/GITR and plays a role in the interactions between activated T-lymphocytes and endothelial cells, potentially influencing T-lymphocyte survival in peripheral tissues. It is expressed at high levels in various organs and endothelial cells during inflammation. Osteostat inhibits the differentiation of osteoclasts from precursor cells and suppresses the early stage of osteoclast formation by blocking the expression of RANK. This cytokine does not interfere with RANK expression in monocytes, dendritic cells, or T cells. Osteostat appears to be a key regulator of osteoclast generation and highlights the significant influence of endothelial cells on bone health.

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  • Sku: PSB-cyt-807-2µg
  • Vendor: ProSpec-Tany
$60.00 USD
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Safety Data Sheet
UniProt Listing
NCBI Link

Product Details

Product Description

Recombinant Human AITRL, T7 Tag is a protein belonging to the tumor necrosis factor (TNF) superfamily. It is commonly used in research and biotechnology applications for its role in immune responses and inflammation. This protein has a molecular weight of approximately 18 kDa and contains a T7 tag for easy detection and purification. Recombinant Human AITRL, T7 Tag is a valuable tool for studying immune system regulation and therapeutic development.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 90% by SDS-PAGE
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 N/A
Structure Dimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Frozen
Formulation AITRL protein solution (0.25mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 10% glycerol and 0.4M Urea.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MASMTGGQQM GRGSHMAKFG PLPSKWQMAS SEPPCVNKVS DWKLEILQNG LYLIYGQVAP NANYNDVAPF EVRLYKNKDM IQTLTNKSKI QNVGGTYELH VGDTIDLIFN SEHQVLKNNT YWGIILLANP QFIS.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution
​

References

Not Available
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AITRL, T7
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