AITRL, His

Alternative Names: Tumor necrosis factor ligand superfamily member 18, TNFSF18, Activation-induced TNFR member Ligand, AITRL, Glucocorticoid-induced TNF-related ligand, GITRL, hGITRL, Osteostat, MGC138237, TL6

Osteostat is a cytokine that binds to TNFRSF18/AITR/GITR, facilitating interactions between activated T-lymphocytes and endothelial cells. It is highly expressed in certain tissues such as the small intestine, ovary, testis, kidney, and endothelial cells after exposure to lipopolysaccharides. Osteostat protein is present in human microvascular EC and is upregulated by IFN-alpha and IFN-beta. It inhibits the differentiation of osteoclasts from monocytic precursor cells by suppressing the early stage of osteoclastogenesis. Osteostat does not inhibit RANK expression in monocytes, dendritic cells, or T cells. This cytokine is a novel regulator of osteoclast formation and highlights the significant role of the endothelium in bone physiology.

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  • Sku: PSB-cyt-317-5µg
  • Vendor: ProSpec-Tany
$60.00 USD
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Title

Product Details

Product Description

Recombinant Human AITRL, His Tag is a protein belonging to the TNF superfamily. It is commonly used in research and therapeutic applications due to its ability to regulate immune responses. This protein has a molecular weight of approximately 21 kDa and is produced in a mammalian expression system. Recombinant Human AITRL, His Tag is a valuable tool for studying immune system function and developing new treatments for various diseases.

Current Lead Time

7-14 Days

Product Specifications

Species
Human
Expression System E. coli
Purity 85.0% by SDS-PAGE
Activity
Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
N/A
Structure Dimer
Endotoxin Concentration
Not Available
Purification Method Not Available
Form
Frozen
Formulation AITRL protein solution (1mg/ml) contains 20mM Tris-HCl buffer (pH8.0) & 10% glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MQLETAKEPC MAKFGPLPSK WQMASSEPPC VNKVSDWKLE ILQNGLYLIY GQVAPNANYN DVAPFEVRLY KNKDMIQTLT NKSKIQNVGG TYELHVGDTI DLIFNSEHQV LKNNTYWGII LIANPQEISL EHHHHHH.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution

References

Not Available

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AITRL, His

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