Ag85B

Alternative Names: Antigen 85-B, 85B, Antigen 85 complex B, Ag85B, Mycolyl transferase 85B, EC 2.3.1.-, Extracellular alpha-antigen, Fibronectin-binding protein B, 30 kDa extracellular protein, fbpB, A85B, Major Secretory Protein Antigen 85B.

Antigen 85B (Ag85B) is the most abundant protein found in M. tuberculosis and is considered an important immunoprotective antigen and drug target. In healthy individuals, as well as in BCG-vaccinated mice and humans, Ag85B triggers a robust T-cell proliferation and IFN-g secretion. However, active tuberculosis patients tend to have a higher prevalence of antibodies against Ag85B, which coincides with a decrease in cellular immune response.

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  • Sku: PSB-pro-589-2µg
  • Vendor: ProSpec-Tany
$60.00 USD
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Title

Product Details

Product Description

Recombinant Mycobacterium Tuberculosis major secretory protein Antigen 85B, a member of the Antigen 85 family, is a significant protein involved in the pathogenesis of tuberculosis. This protein plays a crucial role in the synthesis and transport of mycolic acids, which are essential components of the mycobacterial cell wall. With a molecular weight of approximately 30 kDa, Antigen 85B exhibits high immunogenicity and is considered a promising candidate for the development of tuberculosis vaccines and diagnostic tools. Its precise function and interactions within the complex mycobacterial network make it a subject of extensive research in the field of tuberculosis immunology.

Current Lead Time

7-14 Days

Product Specifications

Species
Bacteria
Expression System E. coli
Purity 90% by SDS-PAGE
Activity
Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
N/A
Structure Homodimer
Endotoxin Concentration
Not Available
Purification Method Not Available
Form
Lyophilized
Formulation Lyophilized with no additives.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MRGSHHHHHHFSRPGLPVEYLQVPSPSMGRDIKVQFQSGGNNSPAVYLLDGLRAQDDYNGWDINTPAFEWYYQSGLSIVMPVGGQSSFYSDWYSPACGKAGCQTYKWETFLTSELPQWLSANRAVKPTGSAAIGLSMAGSSAMILAAYHPQQFIYAGSLSALLDPSQGMGPSLIGLAMGDAGGYKAADMWGPSSDPAWERNDPTQQIPKLVANNTRLWVYCGNGTPNELGGANIPAEFLENFVRSSNLKFQDAYNAAGGHNAVFNFPPNGTHSWEYWGAQLNAMKGDLQSSLGAG.

Storage Instruction

Ag85B although stable room temperature for 4 weeks, should be stored desiccated below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.

Sample Prep Instruction

It is recommended to reconstitute the lyophilized Antigen-85B in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

References

Not Available

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Ag85B

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