ADPRHL2

Alternative Names: Poly(ADP-ribose) glycohydrolase ARH3, ADP-ribosylhydrolase 3, ADPRHL2, [Protein ADP-ribosylarginine] hydrolase-like protein 2, ARH3.

ADP-ribosylhydrolase like 2 (ADPRHL2) is an enzyme that belongs to the ADP-ribosylglycohydrolase family. It catalyzes the removal of ADP-ribose from ADP-ribosylated proteins, using magnesium as a cofactor. ADPRHL2 is expressed in various tissues and plays a key role in the hydrolysis of poly(ADP-ribose) generated in response to DNA damage. Additionally, ADPRHL2 is involved in maintaining normal neuronal cell function and is found in the mitochondria, nucleus, and cytoplasm.

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  • Sku: PSB-enz-638-5µg
  • Vendor: ProSpec-Tany
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UniProt Listing
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Product Details

Product Description

Recombinant Human ADP-Ribosylhydrolase Like 2 is a member of the ADP-ribosylglycohydrolase family, which plays a role in the hydrolysis of ADP-ribose polymers. With a molecular weight of approximately 42 kDa, this enzyme is involved in the regulation of various cellular processes by catalyzing the cleavage of ADP-ribose from proteins. Recombinant Human ADP-Ribosylhydrolase Like 2 is commonly used in research settings to study the functions of ADP-ribosylation and its impact on cellular signaling pathways.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 90% by SDS-PAGE
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 41.5 kDa
Structure Homodimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Frozen
Formulation The ADPRHL2 solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.1M NaCl, 30% glycerol and 1mM DTT.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MGSHMAAAAM AAAAGGGAGA ARSLSRFRGC LAGALLGDCV GSFYEAHDTV DLTSVLRHVQ SLEPDPGTPG SERTEALYYT DDTAMARALV QSLLAKEAFD EVDMAHRFAQ EYKKDPDRGY GAGVVTVFKK LLNPKCRDVF EPARAQFNGK GSYGNGGAMR VAGISLAYSS VQDVQKFARL SAQLTHASSL GYNGAILQAL AVHLALQGES SSEHFLKQLL GHMEDLEGDA QSVLDARELG MEERPYSSRL KKIGELLDQA SVTREEVVSE LGNGIAAFES VPTAIYCFLR CMEPDPEIPS AFNSLQRTLI YSISLGGDTD TIATMAGAIA GAYYGMDQVP ESWQQSCEGY EETDILAQSL HRVFQKS.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution
​

References

Not Available
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ADPRHL2
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