ADFP

Alternative Names: Adipophilin, Adipose differentiation-related protein, ADRP, ADFP, MGC10598.

ADFP is an important component of the surface membrane of lipid droplets. It is found in the globule surface and its expression levels can be assessed through mRNA levels. In the case of Mycobacterium leprae infection, ADFP expression is regulated to promote the accumulation of lipids within infected macrophages for survival. ADFP is also present in lipid droplets of hepatic stellate cells that store vitamin A, as well as lipid droplets of steatotic hepatocytes. Furthermore, ADFP expression plays a role in the differentiation of clear cell renal carcinoma. It is worth noting that ADFP is also found in the lipid droplets of THP-1 cells.

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  • Sku: PSB-pro-405-2µg
  • Vendor: ProSpec-Tany
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Safety Data Sheet
UniProt Listing
NCBI Link

Product Details

Product Description

Recombinant Human Adipose Differentiation-Related Protein (ADRP) is a protein that plays a crucial role in adipocyte differentiation and lipid droplet formation. Belonging to the perilipin family, ADRP is primarily expressed in adipose tissue and is involved in the regulation of lipid metabolism. With a molecular weight of approximately 50 kDa, this protein is known for its ability to coat lipid droplets, facilitating their growth and stabilization. ADRP's significance lies in its contribution to adipogenesis and lipid storage, making it a valuable target for studying obesity-related disorders and metabolic diseases.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 95% by SDS-PAGE
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 N/A
Structure Dimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Lyophilized
Formulation Human ADFP was lyophilized from 0.5mg/ml solution containing 20mM Tris pH-7.5, and 20mM NaCl.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MKHHHHHHAS VAVDPQPSVV TRVVNLPLVS STYDLMSSAY LSTKDQYPYL KSVCEMAENG VKTITSVAMT SALPIIQKLE PQIAVANTYA CKGLDRIEER LPILNQPSTQ IVANAKGAVT GAKDAVTTTV TGAKDSVAST ITGVMDKTKG AVTGSVEKTK SVVSGSINTV LGSRMMQLVS SGVENALTKS ELLVEQYLPL TEEELEKEAK KVEGFDLVQK PSYYVRLGSL STKLHSRAYQ QALSRVKEAK QKSQQTISQL HSTVHLIEFA RKNVYSANQK IQDAQDKLYL SWVEWKRSIG YDDTDESHCA EHIESRTLAI ARNLTQQLQT TCHTLLSNIQ GVPQNIQDQA KHMGVMAGDI YSVFRNAASF KEVSDSLLTS SKGQLQKMKE SLDDVMDYLV NNTPLNWLVG PFYPQLTESQ NAQDQGAEMD KSSQETQRSEHKTH.

Storage Instruction

Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C. Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C.

Sample Prep Instruction

Add deionized water to prepare a working stock solution of approximately 0.5mg/mL and let the lyophilized pellet dissolve completely. Product is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture.

References

Not Available
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ADFP
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