ACTN1

Alternative Names: Not Available

ACTN1 is responsible for encoding a specific type of nonmuscle, cytoskeletal alpha actinin. This gene is found in the same location as the erythroid beta spectrin gene, which is structurally similar. Alpha actinins are part of the spectrin gene superfamily, a varied group of cytoskeletal proteins that includes alpha and beta spectrins and dystrophins. Alpha actinin is a protein that binds to actin and serves multiple functions depending on the cell type. In nonmuscle cells, the cytoskeletal isoform can be found along microfilament bundles and adherens-type junctions, where it helps bind actin to the cell membrane. Conversely, skeletal, cardiac, and smooth muscle isoforms localize to the Z-disc and similar dense bodies, where they play a role in anchoring myofibrillar actin filaments.

  •
  • Sku: PSB-pro-2227-5µg
  • Vendor: ProSpec-Tany
$60.00 USD
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Safety Data Sheet
UniProt Listing
NCBI Link

Product Details

Product Description

Recombinant Human Actinin Alpha 1 is a protein that belongs to the actin-binding protein family. With a weight of approximately 100 kDa, this protein plays a significant role in maintaining cell structure and facilitating cell movement. Actinin Alpha 1 is involved in cross-linking actin filaments, contributing to the organization and stability of the cytoskeleton. This recombinant protein is widely used in scientific research to investigate cellular processes and study the interactions between actin and other cellular components.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 95% by SDS-PAGE
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 31.4 kDa
Structure Homodimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Frozen
Formulation ACTN1 protein solution (1mg/ml) containing Phosphate Buffered Saline (pH7.4) and 10% glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MGSEFMDHYD SQQTNDYMQP EEDWDRDLLL DPAWEKQQRK TFTAWCNSHL RKAGTQIENI EEDFRDGLKL MLLLEVISGE RLAKPERGKM RVHKISNVNK ALDFIASKGV KLVSIGAEEI VDGNVKMTLG MIWTIILRFA IQDISVEETS AKEGLLLWCQ RKTAPYKNVN IQNFHISWKD GLGFCALIHR HRPELIDYGK LRKDDPLTNL NTAFDVAEKY LDIPKMLDAE DIVGTARPDE KAIMTYVSSF YHAF.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution
​

References

Not Available
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ACTN1
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