ACTA2

Alternative Names: Actin Alpha 2 Smooth Muscle Aorta, Actin Aortic Smooth Muscle, Alpha-Cardiac Actin, Alpha-Actin-2, Cell Growth-Inhibiting Gene 46 Protein, MYMY5, ACTSA, ACTVS, AAT6.

ACTA2 is a highly conserved protein belonging to the actin family, which plays a critical role in cellular processes such as movement, structural support, and maintaining integrity. Within this family, there are three known isoforms: Alpha, beta, and gamma. Alpha actins are primarily involved in muscle contraction, while beta and gamma actins contribute to the regulation of cell movement. Specifically, ACTA2 is an alpha actin that is predominantly found in skeletal muscle. Mutations in ACTA2 have been linked to a specific form of thoracic aortic aneurysm, known as familial thoracic type 6. Interestingly, multiple variants of ACTA2, all encoding the same protein, have been identified through alternative splicing.

  •
  • Sku: PSB-pro-1220-2µg
  • Vendor: ProSpec-Tany
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Safety Data Sheet
UniProt Listing
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Product Details

Product Description

Recombinant Human Actin, Alpha 2, Smooth Muscle, Aorta is a protein derived from the smooth muscle tissue of the aorta. Belonging to the actin protein family, it plays a significant role in the contraction and relaxation of smooth muscle cells. With a molecular weight of approximately X kDa, this protein is involved in various physiological processes, including vascular tone regulation and smooth muscle cell migration. Its precise functions and interactions make it a valuable target for research in the field of cardiovascular diseases.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 85.0% by SDS-PAGE
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 N/A
Structure Dimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Frozen
Formulation The ACTA2 solution contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl and 10% glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MGSHMEEEDS TALVCDNGSG LCKAGFAGDD APRAVFPSIV GRPRHQGVMV GMGQKDSYVG DEAQSKRGIL TLKYPIEHGI ITNWDDMEKI WHHSFYNELR VAPEEHPTLL TEAPLNPKAN REKMTQIMFE TFNVPAMYVA IQAVLSLYAS GRTTGIVLDS GDGVTHNVPI YEGYALPHAI MRLDLAGRDL TDYLMKILTE RGYSFVTTAE REIVRDIKEK LCYVALDFEN EMATAASSSS LEKSYELPDG QVITIGNERF RCPETLFQPS FIGMESAGIH ETTYNSIMKC DIDIRKDLYA NNVLSGGTTM YPGIADRMQK EITALAPSTM KIKIIAPPER KYSVWIGGSI LASLSTFQQM WISKQEYDEA GPSIVHRKCF.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution
​

References

Not Available
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ACTA2
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