ACOT11

Alternative Names: Acyl-CoA Thioester Hydrolase 11, Acyl-Coenzyme A Thioesterase 11, Adipose Associated Thioesterase, Adipose-Associated Thioesterase, Brown Fat-Inducible Thioesterase, Thioesterase Superfamily Member 1, Thioesterase, Acyl-CoA Thioesterase 11, STARD14, START Domain Containing 14, StAR-Related Lipid Transfer (START) Domain Containing 14, THEM1, THEA, BFIT, BFIT1, BFIT2, KIAA0707, EC 3.1.2.1.

ACOT11 is a member of the acyl-CoA thioesterase family responsible for converting activated fatty acids into non-esterified fatty acids and coenzyme A. Its expression in brown adipose tissue is influenced by temperature, being induced by low temperatures and inhibited by high temperatures. Mice resistant to obesity show higher levels of ACOT11 expression compared to obesity-prone mice, suggesting a potential role of ACOT11 in obesity. Additionally, ACOT11 shows thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates.

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  • Sku: PSB-enz-756-5µg
  • Vendor: ProSpec-Tany
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UniProt Listing
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Product Details

Product Description

Recombinant Human Acyl-CoA Thioesterase 11 is an enzyme belonging to the thioesterase family, specifically involved in the hydrolysis of fatty acyl-CoA esters. With a molecular weight of approximately 41 kDa, this enzyme plays a significant role in lipid metabolism by catalyzing the cleavage of acyl-CoA thioester bonds. Recombinant Human Acyl-CoA Thioesterase 11 is a valuable tool in research and biotechnological applications due to its ability to modulate cellular lipid levels and influence various metabolic pathways.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 90% by SDS-PAGE
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 29.9 kDa
Structure Homodimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Frozen
Formulation ACOT11 protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH8.0), 0.4M Urea and 10% glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSNRTS RKSALRAGND SAMADGEGYR NPTEVQMSQL VLPCHTNQRG ELSVGQLLKW IDTTACLSAE RHAGCPCVTA SMDDIYFEHT ISVGQVVNIK AKVNRAFNSS MEVGIQVASE DLCSEKQWNV CKALATFVAR REITKVKLKQ ITPRTEEEKM EHSVAAERRR MRLVYADTIK DLLANCAIQG DLESRDCSRM VPAEKTRVES VELVLPPHAN HQGNTFGGQI MAWMENVA

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution
​

References

Not Available
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ACOT11
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