ACE2 (18-740), Fc

Alternative Names: Not Available

ACE-2 is a transmembrane enzyme found in various organs, serving as an entry receptor for SARS coronaviruses, including SARS-CoV-2. The spike (S) glycoprotein on the virus envelope plays a critical role in infection by binding to host cell receptors and facilitating fusion with cellular membranes. Within the S1 domain of the spike protein, two main regions have been identified: the N-terminal and C-terminal domains, one or both of which functions as a receptor-binding domain. Both SARS-CoV and MERS-CoV viruses utilize the C-domain of the spike protein to attach to their receptors. ACE2 is a type I transmembrane protein with an extracellular N-terminal domain containing a catalytic site and an intracellular C-terminal tail. This enzyme functions as a mono-carboxypeptidase, degrading Angiotensin I to produce Ang 1-9 and Angiotensin II to generate Ang 1-7.

Skip to product information
  • Sku: PSB-enz-1126-50µg
  • Vendor: ProSpec-Tany
$900.00 USD
 per 
Shipping calculated at checkout.

Contact us directly for international purchases.

Title

Product Details

Product Description

Recombinant Human Angiotensin Converting Enzyme 2 (18-740 a.a.), Fc Tag is a protein belonging to the angiotensin-converting enzyme family. With a molecular weight of approximately 120 kDa, this enzyme plays a role in the renin-angiotensin system by cleaving angiotensin I to produce angiotensin 1-9, which has vasodilatory effects. This protein is commonly used in research studies investigating the pathophysiology of cardiovascular diseases and as a potential therapeutic target for conditions such as hypertension and heart failure.

Current Lead Time

7-14 Days

Product Specifications

Species
Human
Expression System HEK 293
Purity 95% by SDS-PAGE
Activity
Not Available
Activity Assay
Animal Component Free (ACF) No
Molecular Weight
N/A
Structure Dimer
Endotoxin Concentration
Not Available
Purification Method Not Available
Form
Frozen
Formulation ACE2 Human protein solution is supplied in 50mM Tris-HCl, pH7.5, and 150mM NaCl and glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution

References

Not Available

View full details

ACE2 (18-740), Fc

SUBHEADING

Recently viewed products