ACE2 (18-740), Biotin

Alternative Names: Not Available

ACE-2 is an enzyme found in various organs like the intestines, arteries, lungs, heart, and kidneys. It acts as an entry receptor for SARS coronaviruses, including SARS-CoV-2. The spike glycoprotein on the virus is crucial for infecting host cells. There are two main domains within this glycoprotein, the N-terminal and C-terminal domains. The C-domain is used by both SARS-CoV and MERS-CoV to attach to their receptors. ACE2 is a transmembrane antigen with a catalytic site in the N-terminal domain. It functions as a carboxypeptidase by degrading angiotensin I and II into smaller peptides.

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  • Sku: PSB-enz-1127-1µg
  • Vendor: ProSpec-Tany
$100.00 USD
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Title

Product Details

Product Description

Recombinant Human Angiotensin Converting Enzyme 2 (18-740 a.a.), Biotinylated is a biotinylated form of the enzyme ACE2, a member of the angiotensin-converting enzyme family. This enzyme plays a key role in the renin-angiotensin system, which regulates blood pressure and fluid balance. With a molecular weight of approximately 85 kDa, Recombinant Human Angiotensin Converting Enzyme 2 (18-740 a.a.), Biotinylated is commonly used in research studies to investigate its interactions with the SARS-CoV-2 virus and potential therapeutic interventions.

Current Lead Time

7-14 Days

Product Specifications

Species
Human
Expression System HEK 293
Purity 90% by SDS-PAGE
Activity
Not Available
Activity Assay
Animal Component Free (ACF) No
Molecular Weight
N/A
Structure Dimer
Endotoxin Concentration
Not Available
Purification Method Not Available
Form
Frozen
Formulation ACE2 Human protein solution is supplied in 50mM Tris, pH7.5, 150mM NaCl and 20% glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution

References

Not Available

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ACE2 (18-740), Biotin

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