AASDHPPT

Alternative Names: Alpha-aminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase, AASD-PPT, AASDHPPT, L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase, LYS2, LYS5, LYS5 ortholog, 4'-phosphopantetheinyl transferase, CGI-80, DKFZp566E2346.

AASDHPPT belongs to the P-Pant transferase superfamily and is responsible for modifying target proteins using phosphopantetheine. It can transfer the 4'-phosphopantetheine moiety from coenzyme A to various acceptors, like the acyl carrier domain of FASN. AASDHPPT is similar to Saccharomyces cerevisiae LYS5 and is necessary for activating alpha-aminoadipate dehydrogenase in lysine biosynthesis. AASDHPPT is present in multiple tissues, including the heart, skeletal muscle, placenta, testis, brain, pancreas, liver, and kidney. It has been proposed that mutations in the AASDHPPT gene may lead to pipecolic acidemia.

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  • Sku: PSB-enz-008-5µg
  • Vendor: ProSpec-Tany
$60.00 USD
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Safety Data Sheet
UniProt Listing
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Product Details

Product Description

Recombinant Human Aminoadipate-Semialdehyde Dehydrogenase-Phosphopantetheinyl Transferase is an enzyme that plays a key role in the biosynthesis of lysine and fatty acids. Belonging to the aldehyde dehydrogenase family, this enzyme has a molecular weight of approximately 60 kDa. Its function involves catalyzing the transfer of the phosphopantetheine moiety from coenzyme A to a lysine residue on the acyl carrier protein, facilitating the biosynthesis of essential cellular components.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 95% by SDS-PAGE
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 36.4 kDa
Structure Homodimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Frozen
Formulation The AASDHPPT solution (1mg/ml) contains 20mM Tris-HCl Buffer (pH 8.0), 1mM DTT and 10% Glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MEGVRWAFSC GTWLPSRAEW LLAVRSIQPE EKERIGQFVF ARDAKAAMAG RLMIRKLVAE KLNIPWNHIR LQRTAKGKPV LAKDSSNPYP NFNFNISHQG DYAVLAAEPE LQVGIDIMKT SFPGRGSIPE FFHIMKRKFT NKEWETIRSF KDEWTQLDMF YRNWALKESF IKAIGVGLGF ELQRLEFDLS PLNLDIGQVY KETRLFLDGE EEKEWAFEES KIDEHHFVAV ALRKPDGSRH QDVPSQDDSK PTQRQFTILN FNDLMSSAVP MTPEDPSFWD CFCFTEEIPI RNGTKS.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution
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References

Not Available
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