AARS

Alternative Names: Alanyl-tRNA synthetase cytoplasmic, Alanine-tRNA ligase, AlaRS, EC 6.1.1.7, AARS, PL-12, Renal carcinoma antigen NY-REN-42

Alanyl-tRNA synthetase is a 108 kDa protein that belongs to the aminoacyl-tRNA synthetase family. It plays a crucial role in protein biosynthesis by charging tRNA molecules with specific amino acids. PL-12 antibodies, found in some patients with polymyositis and dermatomyositis, target alanyl-tRNA synthetase as an autoantigen. Research indicates that epitope spreading may lead to the development of antibodies against isolated alanyl-tRNA molecules within the autoimmune response to PL-12.

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  • Sku: PSB-enz-305-5µg
  • Vendor: ProSpec-Tany
$60.00 USD
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Title

Product Details

Product Description

Recombinant Human Alanyl t-RNA Synthetase is an enzyme that belongs to the aminoacyl-tRNA synthetase family. It plays a critical role in protein synthesis by catalyzing the attachment of alanine to its corresponding transfer RNA molecule. With a molecular weight of approximately 110 kDa, this enzyme is essential for the accurate translation of genetic information from DNA to protein. Its recombinant form is commonly used in research and biotechnology applications to study protein synthesis mechanisms and develop novel therapies for various diseases.

Current Lead Time

7-14 Days

Product Specifications

Species
Human
Expression System Sf9 - Insect cells
Purity 90 by SDS-PAGE
Activity
Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
N/A
Structure Homodimer
Endotoxin Concentration
Not Available
Purification Method Not Available
Form
Frozen
Formulation AARSis supplied in16mM HEPES buffer pH-8, 250mM sodium chloride, and 20% glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

Check Uniprot Link

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution

References

Not Available

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AARS

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