A2M

Alternative Names: Alpha-2-macroglobulin, Alpha-2-M, A2M, alpha 2M, CPAMD5, DKFZp779B086, FWP007, S863-7.

Alpha-2 Macroglobulin (A2M) is a liver-produced, large plasma protein composed of four identical subunits bound together by -S-S- bonds. It acts as an inhibitor for various proteases, including thrombin, Kallikrein, plasmin, and multiple other types. A2M contains a 35 amino acid "bait" region that proteinases bind to and cleave, resulting in their attachment to A2M. Macrophage receptors recognize this proteinase-A2M complex and eliminate it from the system. A2M also aids in the removal of MMP-2 and MMP-9 from circulation, using scavenger receptors on phagocytes. The levels of A2M in the body increase in nephrotic syndrome, a condition where the kidneys start leaking smaller blood proteins. As A2M is too large to pass through, its concentration remains elevated. Furthermore, increased production of all proteins contributes to the rise in A2M concentration. Chronic renal failure can potentially lead to the formation of amyloid by alpha-2-macroglobulin. A2M levels are also elevated in cirrhosis, pregnancy, and diabetes.

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  • Sku: PSB-pro-551-200µg
  • Vendor: ProSpec-Tany
$100.00 USD
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Safety Data Sheet
UniProt Listing
NCBI Link

Product Details

Product Description

Human Alpha-2 Macroglobulin Protein is a large plasma glycoprotein that plays a significant role in various physiological processes. Belonging to the alpha-2 macroglobulin family, this protein acts as a broad-spectrum protease inhibitor, regulating proteolytic activity within the body. With a weight of approximately 720 kDa, it forms high-molecular-weight complexes with target proteases, thereby inhibiting their enzymatic function. This protein's intricate mechanism and involvement in protease regulation make it a subject of interest in numerous biomedical research studies.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System Human Plasma
Purity 95.0 % by SDS-PAGE
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) No
Molecular Weight
 N/A
Structure Monomer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Lyophilized
Formulation Lyophilized from a concentrated solution containing 5mM potassium phosphate buffer, pH 6.5 and 1:1 ratio (w/w) of Glycine.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

Check Uniprot Link

Storage Instruction

Lyophilized A2M protein although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution and filter sterilization A2M can be stored at 4°C for up to 4 weeks. For long term storage and more diluted solutions it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.

Sample Prep Instruction

It is recommended to reconstitute the lyophilized A2M in sterile 18MΩ-cm H₂O.

References

Not Available
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A2M
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