4-1BBL

Alternative Names: CD137L, CD137-L, TNFSF9, Tumor Necrosis Factor (ligand) Superfamily Member 9, 4-1BBL, 4-1BB Ligand

4-1BBL, a transmembrane cytokine belonging to the TNF ligand family, acts as a bidirectional signal transducer for the T lymphocyte receptor TNFRSF9. This interaction plays a role in antigen presentation and cytotoxic T cell generation. Activation of 4-1BBR occurs upon antigenic stimulation, leading to the reactivation of anergic T lymphocytes and promoting T cell proliferation. Optimal CD8 responses in CD8 T cells require 4-1BB Ligand. 4-1BBL is expressed in carcinoma cell lines and plays a role in T cell-tumor cell interaction. Additionally, it is expressed in various immune cells, neurons, and astrocytes. The interaction between 4-1BB and TNFRSF9 strongly regulates immunity, particularly in controlling T cell responses as shown in murine studies.

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  • Sku: PSB-cyt-149-5µg
  • Vendor: ProSpec-Tany
$60.00 USD
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Safety Data Sheet
UniProt Listing
NCBI Link

Product Details

Product Description

Recombinant Human 4-1BB Ligand is a protein belonging to the TNF superfamily. It plays a role in the regulation of immune responses and has been studied for its potential therapeutic applications in cancer immunotherapy. With a molecular weight of approximately 20-25 kDa, Recombinant Human 4-1BB Ligand is produced through recombinant DNA technology and is commonly used in research settings to study its interactions with the 4-1BB receptor and its effects on immune cell activation.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 95% by SDS-PAGE
Activity
 Fully biologically active when compared to standard. Determined by the dose-dependent stimulation of IL-8 production by human PBMC. The ED50 for this effect is 5-10ng/ml corresponding to a Specific Activity of 100,000-200,000IU/mg. Fully biologically active when compared to standard. Determined by the dose-dependent stimulation of IL-8 production by human PBMC. The ED50 for this effect is 5-10ng/ml corresponding to a Specific Activity of 100,000-200,000IU/mg.
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 19.5 kDa
Structure Homodimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Lyophilized
Formulation Lyophilized from a 0.2µm filtered concentrated solution in PBS, pH 7.4.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

REGPELSPDD PAGLLDLRQG MFAQLVAQNV LLIDGPLSWY SDPGLAGVSL TGGLSYKEDT KELVVAKAGV YYVFFQLELR RVVAGEGSGS VSLALHLQPL RSAAGAAALA LTVDLPPASS EARNSAFGFQ GRLLHLSAGQ RLGVHLHTEA RARHAWQLTQ GATVLGLFRV TPEIPAGLPS PRSE

Storage Instruction

Lyophilized 4 1BBL although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution 4 1BBL should be stored at 4°C between 2-7 days and for future use below -18°C.Please prevent freeze-thaw cycles.

Sample Prep Instruction

It is recommended to reconstitute the lyophilized 4 1BBL in sterile 18M-cm H₂O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

References

Not Available
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4-1BBL
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