4-11BBL, His

Alternative Names: CD137L, CD137-L, TNFSF9, Tumor Necrosis Factor (ligand) Superfamily Member 9, 4-1BBL, 4-1BB Ligand

4-1BBL is a transmembrane cytokine that belongs to the TNF ligand family. It acts as a ligand for TNFRSF9, a receptor found on T lymphocytes, playing a role in antigen presentation and the generation of cytotoxic T cells. 4-1BBL is rapidly expressed upon antigen stimulation, reactivating anergic T cells and promoting T lymphocyte proliferation. It is essential for optimal CD8 responses in CD8 T cells. 4-1BBL is present in carcinoma cell lines and is involved in T cell-tumor cell interaction. It is also expressed in activated B cells, macrophages, dendritic cells, T cells, neurons, and astrocytes. The interaction between 4-1BB and TNFRSF9 plays a key role in regulating immunity, particularly T cell responses, based on studies in mice.

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  • Sku: PSB-cyt-649-5µg
  • Vendor: ProSpec-Tany
$60.00 USD
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UniProt Listing
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Product Details

Product Description

Recombinant Human 4-1BB Ligand, His Tag is a protein belonging to the tumor necrosis factor (TNF) superfamily. It plays a role in immune responses and cell survival by binding to its receptor, 4-1BB. This ligand is commonly used in research and therapeutic applications due to its ability to activate immune cells. With a molecular weight of approximately 21 kDa, Recombinant Human 4-1BB Ligand, His Tag is a valuable tool for studying immune system function and developing immunotherapy strategies.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 95% by SDS-PAGE
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 N/A
Structure Homodimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Frozen
Formulation Recombinant 4-1BBL solution (1mg/ml) contains 20mM Tris-HCl buffer pH-8, 100mM NaCl and 20% glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSHMRE GPELSPDDPA GLLDLRQGMF AQLVAQNVLL IDGPLSWYSD PGLAGVSLTGGLSYKEDTKE LVVAKAGVYY VFFQLELRRV VAGEGSGSVS LALHLQPLRS AAGAAALALT VDLPPASSEA RNSAFGFQGR LLHLSAGQRL GVHLHTEARA RHAWQLTQGA TVLGLFRVTP EIPAGLPSPR SE.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution
​

References

Not Available
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