CFBb

Alternative Names: Complement factor B (EC:3.4.21.47), C3/C5 convertase, Glycine-rich beta glycoprotein, GBG, PBF2, Properdin factor B, Complement factor B Ba fragment, Complement factor B Bb fragment, CFB, Complement Factor B, BFD, AHUS4, BF, BFD, CFAB, FB, FBI12, H2-Bf.

Complement Factor B, or CFB, produces a component of the alternative pathway of complement activation. It exists as a single chain polypeptide in the blood. When the alternative pathway is triggered, complement factor D cleaves it into noncatalytic chain Ba and catalytic subunit Bb. Bb, a serine protease, interacts with C3b to form the alternative pathway C3 convertase. Additionally, Bb promotes the growth of preactivated B lymphocytes, while Ba prevents their proliferation.

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  • Sku: PSB-pro-2736-10µg
  • Vendor: ProSpec-Tany
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Title

Product Details

Product Description

Human Complement Factor B Fragment b, also known as CFBb, is a component of the complement system, a vital part of the immune response. CFBb belongs to the serine protease family and plays a crucial role in the alternative pathway of the complement system. With a molecular weight of approximately 63 kDa, CFBb acts as a catalyst in the amplification loop of the complement cascade, promoting the opsonization and lysis of pathogens. Its precise enzymatic activity and structural characteristics make CFBb an important target for research and therapeutic interventions in various immune-related disorders.

Current Lead Time

7-14 Days

Product Specifications

Species
Human
Expression System Human Plasma
Purity 95.0 by SDS-PAGE
Activity
Not Available
Activity Assay
Animal Component Free (ACF) No
Molecular Weight
N/A
Structure Monomer
Endotoxin Concentration
Not Available
Purification Method Not Available
Form
Frozen
Formulation CFB-b solution (1mg/ml) contains Phosphate-buffered saline, pH 7.3.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

Check Uniprot Link

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution

References

Not Available

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CFBb

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